| Descriptor English: | Leukodystrophy, Globoid Cell | ||||||
| Descriptor Spanish: |
Leucodistrofia de Células Globoides
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| Descriptor Portuguese: | Leucodistrofia de Células Globoides | ||||||
| Descriptor French: | Leucodystrophie à cellules globoïdes | ||||||
| Entry term(s): |
Cell Leukodystrophies, Globoid Cell Leukodystrophy, Globoid Cell Leukoencephalopathies, Globoid Cell Leukoencephalopathy, Globoid Classic Globoid Cell Leukodystrophy Deficiencies, GALC Deficiencies, Galactocerebrosidase Deficiencies, Galactosylceramide beta-Galactosidase Deficiency Disease, Galactosylceramidase Deficiency Disease, Galactosylceramide-beta-Galactosidase Deficiency Diseases, Galactosylceramidase Deficiency Diseases, Galactosylceramide-beta-Galactosidase Deficiency, GALC Deficiency, Galactocerebrosidase Deficiency, Galactosylceramide beta-Galactosidase Diffuse Globoid Body Sclerosis Disease, Galactosylceramidase Deficiency Disease, Galactosylceramide-beta-Galactosidase Deficiency Diseases, Galactosylceramidase Deficiency Diseases, Galactosylceramide-beta-Galactosidase Deficiency Early Onset Globoid Cell Leukodystrophy Early-Onset Globoid Cell Leukodystrophy GALC Deficiencies GALC Deficiency Galactocerebrosidase Deficiencies Galactocerebrosidase Deficiency Galactosylceramidase Deficiency Disease Galactosylceramidase Deficiency Diseases Galactosylceramide Lipidosis Galactosylceramide beta Galactosidase Deficiency Galactosylceramide beta Galactosidase Deficiency Disease Galactosylceramide beta-Galactosidase Deficiencies Galactosylceramide beta-Galactosidase Deficiency Galactosylceramide-beta-Galactosidase Deficiency Disease Galactosylceramide-beta-Galactosidase Deficiency Diseases Galactosylcerebrosidase Deficiency Galactosylsphingosine Lipidosis Globoid Body Sclerosis, Diffuse Globoid Cell Leukodystrophies Globoid Cell Leukodystrophy Globoid Cell Leukoencephalopathies Globoid Cell Leukoencephalopathy Globoid Leukodystrophies Globoid Leukodystrophy Infantile Globoid Cell Leukodystrophy Krabbe Disease Krabbe Leukodystrophy Krabbe's Disease Krabbe's Leukodystrophy Krabbes Disease Krabbes Leukodystrophy Late Onset Globoid Cell Leukodystrophy Late-Onset Globoid Cell Leukodystrophy Leukodystrophies, Globoid Leukodystrophies, Globoid Cell Leukodystrophy, Globoid Leukodystrophy, Globoid Cell, Classic Leukodystrophy, Globoid Cell, Early-Onset Leukodystrophy, Globoid Cell, Infantile Leukodystrophy, Globoid Cell, Late-Onset Leukodystrophy, Krabbe Leukodystrophy, Krabbe's Leukoencephalopathies, Globoid Cell Leukoencephalopathy, Globoid Cell Psychosine Lipidosis beta-Galactosidase Deficiencies, Galactosylceramide beta-Galactosidase Deficiency, Galactosylceramide |
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| Tree number(s): |
C10.228.140.163.100.362.500 C10.228.140.163.100.435.825.590 C10.228.140.695.625.500 C10.314.400.500 C16.320.565.189.362.500 C16.320.565.189.435.825.590 C16.320.565.398.641.803.585 C16.320.565.595.554.825.590 C18.452.132.100.362.500 C18.452.132.100.435.825.590 C18.452.584.563.641.803.585 C18.452.648.189.362.500 C18.452.648.189.435.825.590 C18.452.648.398.641.803.585 C18.452.648.595.554.825.590 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D007965 | ||||||
| Scope note: | An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses. |
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| Allowable Qualifiers: |
BL blood CF cerebrospinal fluid CI chemically induced CL classification CO complications DG diagnostic imaging DH diet therapy DI diagnosis DT drug therapy EC economics EH ethnology EM embryology EN enzymology EP epidemiology ET etiology GE genetics HI history IM immunology ME metabolism MI microbiology MO mortality NU nursing PA pathology PC prevention & control PP physiopathology PS parasitology PX psychology RH rehabilitation RT radiotherapy SU surgery TH therapy UR urine VE veterinary VI virology |
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| Public MeSH Note: | 1974; see CEREBRAL SCLEROSIS, DIFFUSE 1963-1973; for LEUKODYSTROPHIES see CEREBRAL SCLEROSIS, DIFFUSE 1963-1973; for KRABBE DISEASE see KRABBE'S DISEASE 1974-1997 |
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| History Note: | 1974(1963) |
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| Related: |
Galactosylceramidase
MeSH | ||||||
| DeCS ID: | 8142 | ||||||
| Unique ID: | D007965 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1974/01/01 | ||||||
| Date of Entry: | 1999/01/01 | ||||||
| Revision Date: | 2013/07/08 |
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Leukodystrophy, Globoid Cell
- Preferred
Early-Onset Globoid Cell Leukodystrophy
- Narrower
Late-Onset Globoid Cell Leukodystrophy
- Narrower
| Concept UI |
M0012415 |
| Scope note | An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses. |
| Preferred term | Leukodystrophy, Globoid Cell |
| Entry term(s) |
Cell Leukodystrophies, Globoid Cell Leukodystrophy, Globoid Cell Leukoencephalopathies, Globoid Cell Leukoencephalopathy, Globoid Deficiencies, GALC Deficiencies, Galactocerebrosidase Deficiencies, Galactosylceramide beta-Galactosidase Deficiency Disease, Galactosylceramidase Deficiency Disease, Galactosylceramide-beta-Galactosidase Deficiency Diseases, Galactosylceramidase Deficiency Diseases, Galactosylceramide-beta-Galactosidase Deficiency, GALC Deficiency, Galactocerebrosidase Deficiency, Galactosylceramide beta-Galactosidase Diffuse Globoid Body Sclerosis Disease, Galactosylceramidase Deficiency Disease, Galactosylceramide-beta-Galactosidase Deficiency Diseases, Galactosylceramidase Deficiency Diseases, Galactosylceramide-beta-Galactosidase Deficiency GALC Deficiencies GALC Deficiency Galactocerebrosidase Deficiencies Galactocerebrosidase Deficiency Galactosylceramidase Deficiency Disease Galactosylceramidase Deficiency Diseases Galactosylceramide Lipidosis Galactosylceramide beta Galactosidase Deficiency Galactosylceramide beta Galactosidase Deficiency Disease Galactosylceramide beta-Galactosidase Deficiencies Galactosylceramide beta-Galactosidase Deficiency Galactosylceramide-beta-Galactosidase Deficiency Disease Galactosylceramide-beta-Galactosidase Deficiency Diseases Galactosylcerebrosidase Deficiency Galactosylsphingosine Lipidosis Globoid Body Sclerosis, Diffuse Globoid Cell Leukodystrophies Globoid Cell Leukodystrophy Globoid Cell Leukoencephalopathies Globoid Cell Leukoencephalopathy Globoid Leukodystrophies Globoid Leukodystrophy Krabbe Disease Krabbe Leukodystrophy Krabbe's Disease Krabbe's Leukodystrophy Krabbes Disease Krabbes Leukodystrophy Leukodystrophies, Globoid Leukodystrophies, Globoid Cell Leukodystrophy, Globoid Leukodystrophy, Krabbe Leukodystrophy, Krabbe's Leukoencephalopathies, Globoid Cell Leukoencephalopathy, Globoid Cell Psychosine Lipidosis beta-Galactosidase Deficiencies, Galactosylceramide beta-Galactosidase Deficiency, Galactosylceramide |
| Concept UI |
M0335502 |
| Preferred term | Early-Onset Globoid Cell Leukodystrophy |
| Entry term(s) |
Classic Globoid Cell Leukodystrophy Early Onset Globoid Cell Leukodystrophy Infantile Globoid Cell Leukodystrophy Leukodystrophy, Globoid Cell, Classic Leukodystrophy, Globoid Cell, Early-Onset Leukodystrophy, Globoid Cell, Infantile |
| Concept UI |
M0335507 |
| Preferred term | Late-Onset Globoid Cell Leukodystrophy |
| Entry term(s) |
Late Onset Globoid Cell Leukodystrophy Leukodystrophy, Globoid Cell, Late-Onset |
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