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Descriptor English: Lewis Blood Group Antigens
Descriptor Spanish: Antígenos del Grupo Sanguíneo de Lewis
Descriptor antígenos del grupo sanguíneo de Lewis
Entry term(s) antígeno Lewis
antígenos Le
antígenos Lewis
antígenos asociados a tumores relacionados con el grupo sanguíneo de Lewis
antígenos asociados a tumores relacionados con los antígenos de Lewis
antígenos de Lewis
antígenos relacionados con el grupo sanguíneo de Lewis
antígenos relacionados con el sistema del grupo sanguíneo de Lewis
antígenos sialil-Lewis
sistema Lewis
sistema de Lewis
sistema del grupo sanguíneo Le(a)
sistema del grupo sanguíneo Lewis
sistema del grupo sanguíneo de Lewis
Scope note: Antígenos glucídicos relacionados estructuralmente con el SISTEMA DEL GRUPO SANGUÍNEO ABO. Pueden producirse como modificación de cadenas sacáridas en glicolípidos o glicoproteínas en las superficies celulares o en el plasma, o como oligosacáridos libres en las secreciones. Los antígenos Lewis no se sintetizan en las células sanguíneas. En cambio, los glicolípidos Lewis presentes en el plasma son absorbidos a la superficie de los ERITROCITOS, los LINFOCITOS y las PLAQUETAS. Los fenotipos Le(a) y Le(b) son el resultado de las acciones de dos genes, el gen Le (fucosiltransferasa FUT3) y el gen Se (fucosiltransferasa FUT2), sobre el hidrato de carbono, el glicolípido o la glicoproteína precursores. Otras FUCOSILTRANSFERASAS también pueden sintetizar los antígenos Lewis.
Descriptor Portuguese: Antígenos do Grupo Sanguíneo de Lewis
Descriptor French: Without translation
Entry term(s): Antigens, Lewis
Antigens, Lewis Related
Antigens, Sialyl Lewis
Blood Group Lewis Related Antigens
Blood-Group System, Lewis
Le Antigens
Le(a) Blood Group System
Lewis Antigen Related Tumor Associated Antigens
Lewis Antigen Related Tumor-Associated Antigens
Lewis Antigens
Lewis Blood Group Related Antigens
Lewis Blood Group Related Tumor Associated Antigens
Lewis Blood Group Related Tumor-Associated Antigens
Lewis Blood Group System
Lewis Blood-Group System
Lewis Related Antigens
Lewis System
Sialyl Lewis Antigens
Tree number(s): D23.050.301.290.544
D23.050.705.230.544
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007983
Scope note: Carbohydrate antigens structurally related to the ABH BLOOD-GROUP SYSTEM. They may occur as a modification of saccharide chains on glycolipids or glycoproteins on cell surfaces or in plasma, or as free oligosaccharides in secretions. Lewis antigens are not synthesized in blood cells. Instead Lewis glycolipids present in plasma are absorbed onto the surface of ERYTHROCYTES; LYMPHOCYTES; and PLATELETS. The phenotypes Le(a) and Le(b) are the result of the actions of two genes the Le gene (fucosyltransferase FUT3) and the Se gene (fucosyltransferase FUT2) on the precursor carbohydrate, glycolipid or glycoprotein. Other FUCOSYLTRANSFERASES can also synthesize the Lewis antigens.
Annotation: coordinate with disease /blood, not /immunol nor /genet
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2020; see LEWIS BLOOD GROUP SYSTEM 1974-2019
History Note: 2020 (1963)
DeCS ID: 8159
Unique ID: D007983
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/07/05
Lewis Blood Group Antigens - Preferred
Concept UI M0012441
Scope note Carbohydrate antigens structurally related to the ABH BLOOD-GROUP SYSTEM. They may occur as a modification of saccharide chains on glycolipids or glycoproteins on cell surfaces or in plasma, or as free oligosaccharides in secretions. Lewis antigens are not synthesized in blood cells. Instead Lewis glycolipids present in plasma are absorbed onto the surface of ERYTHROCYTES; LYMPHOCYTES; and PLATELETS. The phenotypes Le(a) and Le(b) are the result of the actions of two genes the Le gene (fucosyltransferase FUT3) and the Se gene (fucosyltransferase FUT2) on the precursor carbohydrate, glycolipid or glycoprotein. Other FUCOSYLTRANSFERASES can also synthesize the Lewis antigens.
Preferred term Lewis Blood Group Antigens
Entry term(s) Blood-Group System, Lewis
Le(a) Blood Group System
Lewis Blood Group System
Lewis Blood-Group System
Lewis System
Sialyl Lewis Antigens - Related but not broader or narrower
Concept UI M000647638
Preferred term Sialyl Lewis Antigens
Entry term(s) Antigens, Sialyl Lewis
Lewis Blood Group Related Antigens - Related but not broader or narrower
Concept UI M000647636
Preferred term Lewis Blood Group Related Antigens
Entry term(s) Antigens, Lewis Related
Blood Group Lewis Related Antigens
Lewis Antigen Related Tumor Associated Antigens
Lewis Antigen Related Tumor-Associated Antigens
Lewis Blood Group Related Tumor Associated Antigens
Lewis Blood Group Related Tumor-Associated Antigens
Lewis Related Antigens
Lewis Antigens - Broader
Concept UI M000647640
Preferred term Lewis Antigens
Entry term(s) Antigens, Lewis
Le Antigens



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