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Descriptor English: Mecamylamine
Descriptor Spanish: Mecamilamina
Descriptor mecamilamina
Scope note: Antagonista nicotínico que se absorbe bien a partir del tracto gastrointestinal y atraviesa la barrera hematoencefálica. Se ha utilizado la mecamilamina como bloqueante ganglionar en el tratamiento de la hipertensión, pero, al igual que la mayoría de los bloqueantes ganglionares, se utiliza en la actualaidad más frecuentemente como herramienta de investigación.
Descriptor Portuguese: Mecamilamina
Descriptor French: Mécamylamine
Tree number(s): D02.455.426.100.080.550.500
D04.075.080.500.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008464
Scope note: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antihypertensive Agents
Ganglionic Blockers
Nicotinic Antagonists
Registry Number: 6EE945D3OK
CAS Type 1 Name: Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-
DeCS ID: 8633
Unique ID: D008464
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Mecamylamine - Preferred
Concept UI M0013160
Scope note A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Preferred term Mecamylamine



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