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Descriptor English: Mechlorethamine
Descriptor Spanish: Mecloretamina
Descriptor mecloretamina
Entry term(s) N-óxido de mostaza nitrogenada
cloretacina
clormetina
mostaza nitrogenada
mustina
óxido de mecloretamina
Scope note: Agente biológico alquilante con efectos citotóxicos debidos a la formación de ADUCTOS DE ADN y enlaces intercatenarios de ADN, por lo que inhibe las células que proliferan rápidamente. El clorhidrato es un antineoplásico que se utiliza en el tratamiento de la ENFERMEDAD DE HODGKIN y el LINFOMA.
Descriptor Portuguese: Mecloretamina
Descriptor French: Chlorméthine
Entry term(s): Bis(2-chloroethyl)methylamine
Caryolysine
Chlorethazine
Chlormethine
Cloramin
Embichin
Hydrochloride N-Oxide, Mechlorethamine
Hydrochloride, Mechlorethamine
Mechlorethamine Hydrochloride
Mechlorethamine Hydrochloride N Oxide
Mechlorethamine Hydrochloride N-Oxide
Mechlorethamine N Oxide
Mechlorethamine N-Oxide
Mechlorethamine Oxide
Methylchlorethamine
Mitomen
Mustargen
Mustine
N-Oxide, Mechlorethamine Hydrochloride
N-Oxide, Nitrogen Mustard
NSC 10107
NSC 762
NSC-10107
NSC-762
NSC10107
NSC762
Nitrogen Mustard
Nitrogen Mustard N Oxide
Nitrogen Mustard N-Oxide
Nitrogranulogen
Nitromin
Tree number(s): D02.455.526.728.650.529
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008466
Scope note: A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Alkylating Agents
Chemical Warfare Agents
Irritants
Antineoplastic Agents, Alkylating
Registry Number: 50D9XSG0VR
CAS Type 1 Name: Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-
Public MeSH Note: MECHLORETHAMINE OXIDE was heading 1963-79; NITROGEN MUSTARD N-OXIDE was indexed under NITROGEN MUSTARD COMPOUNDS 1984-91
Online Note: use MECHLORETHAMINE to search MECHLORETHAMINE OXIDE 1966-79; use MECHLORETHAMINE (NM) to search NITROGEN MUSTARD N-OXIDE (NM) 1984-91
History Note: MECHLORETHAMINE OXIDE was heading 1963-79; NITROGEN MUSTARD N-OXIDE was NITROGEN MUSTARD N-OXIDE (NM) 1984-91
DeCS ID: 8635
Unique ID: D008466
NLM Classification: QV 269
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1963/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01
Mechlorethamine - Preferred
Concept UI M0013168
Scope note A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
Preferred term Mechlorethamine
Entry term(s) Bis(2-chloroethyl)methylamine
Chlorethazine
Chlormethine
Methylchlorethamine
Mustine
Nitrogen Mustard
Cloramin - Narrower
Concept UI M0351947
Preferred term Cloramin
Embichin - Narrower
Concept UI M0013173
Preferred term Embichin
Mechlorethamine Hydrochloride - Narrower
Concept UI M0013174
Preferred term Mechlorethamine Hydrochloride
Entry term(s) Hydrochloride, Mechlorethamine
Mechlorethamine Hydrochloride N-Oxide - Narrower
Concept UI M0330112
Preferred term Mechlorethamine Hydrochloride N-Oxide
Entry term(s) Hydrochloride N-Oxide, Mechlorethamine
Mechlorethamine Hydrochloride N Oxide
N-Oxide, Mechlorethamine Hydrochloride
NSC-762 - Narrower
Concept UI M0013176
Preferred term NSC-762
Entry term(s) NSC 762
NSC762
Mechlorethamine Oxide - Narrower
Concept UI M0013169
Preferred term Mechlorethamine Oxide
Mitomen - Narrower
Concept UI M0351949
Preferred term Mitomen
Mustargen - Narrower
Concept UI M0013175
Preferred term Mustargen
Nitrogranulogen - Narrower
Concept UI M0013170
Preferred term Nitrogranulogen
Nitromin - Narrower
Concept UI M0013172
Preferred term Nitromin
NSC-10107 - Narrower
Concept UI M0351948
Preferred term NSC-10107
Entry term(s) NSC 10107
NSC10107
Caryolysine - Narrower
Concept UI M0013167
Preferred term Caryolysine
Mechlorethamine N-Oxide - Narrower
Concept UI M0330111
Preferred term Mechlorethamine N-Oxide
Entry term(s) Mechlorethamine N Oxide
N-Oxide, Nitrogen Mustard
Nitrogen Mustard N Oxide
Nitrogen Mustard N-Oxide



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