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Descriptor English: Metallothionein
Descriptor Spanish: Metalotioneína
Descriptor metalotioneína
Scope note: Proteína de bajo peso molecular (aproximadamente 10 kD) que se encuentra en el citoplasma de las células de la corteza renal y del hígado. Es rica en residuos cisteinil y no contiene aminoácidos aromáticos. La metalotioneína muestra elevada afinidad por los metales pesados bivalentes.
Descriptor Portuguese: Metalotioneína
Descriptor French: Métallothionéine
Entry term(s): Isometallothionein
Metallothionein A
Metallothionein B
Metallothionein I
Metallothionein II
Metallothionein IIA
Tree number(s): D12.776.556.670
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008668
Scope note: A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.
Annotation: /biosyn /physiol permitted
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 9038-94-2
CAS Type 1 Name: Metallothioneins
Previous Indexing: Metalloproteins (1973-1974)
Public MeSH Note: 84; was see under METALLOPROTEINS 1975-83
History Note: 84(75); was see under METALLOPROTEINS 1975-83
DeCS ID: 8844
Unique ID: D008668
NLM Classification: QU 55.8
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1974/11/19
Revision Date: 1997/06/20
Metallothionein - Preferred
Concept UI M0013507
Scope note A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.
Preferred term Metallothionein
Metallothionein A - Narrower
Concept UI M0013508
Preferred term Metallothionein A
Metallothionein B - Narrower
Concept UI M0013509
Preferred term Metallothionein B
Metallothionein II - Narrower
Concept UI M0013511
Preferred term Metallothionein II
Metallothionein IIA - Narrower
Concept UI M0013512
Preferred term Metallothionein IIA
Isometallothionein - Narrower
Concept UI M0013506
Preferred term Isometallothionein
Metallothionein I - Narrower
Concept UI M0013510
Preferred term Metallothionein I



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