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Descriptor English: Misonidazole
Descriptor Spanish: Misonidazol
Descriptor misonidazol
Scope note: Nitroimidazol que sensibiliza las células hipóxicas normalmente radiosensibles a la radiación. Puede ser también directamente citotóxico a las células hipóxicas y ha sido propuesto como antineoplásico.
Descriptor Portuguese: Misonidazol
Descriptor French: Misonidazole
Entry term(s): Ro 07 0582
Ro 07-0582
Ro 070582
Ro 7 0582
Ro 7-0582
Ro 70582
alpha-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol
Tree number(s): D02.640.672.530
D03.383.129.308.658.530
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008920
Scope note: A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Antiprotozoal Agents
Radiation-Sensitizing Agents
Registry Number: 8FE7LTN8XE
CAS Type 1 Name: 1H-Imidazole-1-ethanol, alpha-(methoxymethyl)-2-nitro-
Previous Indexing: Imidazoles (1966-1973)
Nitroimidazoles (1974-1978)
Public MeSH Note: 86; was see under NITROIMIDAZOLES 1979-85
History Note: 86(79); was see under NITROIMIDAZOLES 1979-85
DeCS ID: 9109
Unique ID: D008920
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1978/05/03
Revision Date: 2016/05/31
Misonidazole - Preferred
Concept UI M0013924
Scope note A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.
Preferred term Misonidazole
Entry term(s) alpha-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol
Ro 07-0582 - Narrower
Concept UI M0352078
Preferred term Ro 07-0582
Entry term(s) Ro 07 0582
Ro 070582
Ro 7 0582
Ro 7-0582
Ro 70582



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