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Descriptor English: Mitotane
Descriptor Spanish: Mitotano
Descriptor mitotano
Entry term(s) o,p-DDD
orto para-DDD
Scope note: Derivado del insecticida DICLORODIFENILDICLOROETANO que específicamente inhibe las células de la corteza suprarrenal y su producción de hormonas. Se utiliza para tratar tumores corticosuprarrenales y causa daños en el SNC, pero no depresión de la médula ósea.
Descriptor Portuguese: Mitotano
Descriptor French: Mitotane
Entry term(s): Chloditan
Chlodithane
Khloditan
Lysodren
Mytotan
o,p-DDD
ortho,para DDD
ortho,para-DDD
Tree number(s): D02.455.526.439.681
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008939
Scope note: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Hormonal
Registry Number: 78E4J5IB5J
CAS Type 1 Name: Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-
Previous Indexing: DDD/PD (1966-1972)
Public MeSH Note: 73
History Note: 73
DeCS ID: 9129
Unique ID: D008939
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01
Mitotane - Preferred
Concept UI M0013951
Scope note A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Preferred term Mitotane
Entry term(s) Mytotan
o,p-DDD
ortho,para DDD
ortho,para-DDD
Chlodithane - Narrower
Concept UI M0351882
Preferred term Chlodithane
Lysodren - Narrower
Concept UI M0351881
Preferred term Lysodren
Chloditan - Narrower
Concept UI M0351883
Preferred term Chloditan
Entry term(s) Khloditan



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