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Descriptor English: Monoamine Oxidase
Descriptor Spanish: Monoaminooxidasa
Descriptor monoamina oxidasa
Entry term(s) MAO (enzima)
amina oxidasa (con flavina)
Scope note: Enzima que cataliza la desaminación oxidativa de monoaminas naturales. Es una flavoenzima localizada en las membranas mitocondriales de las terminales nerviosas, el hígado y otros órganos. La monoamina oxidasa es importante en la regulación de la degradación metabólica de catecolaminas y serotonina en el tejido nervioso o en tejidos dianas. La monoamina oxidasa hepática tiene un papel defensivo crucial en la desactivación de las monoaminas circulantes o aquellas que, como la tiramina, se originan en el intestino y son absorbidas por la circulación portal. (Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
Descriptor Portuguese: Monoaminoxidase
Descriptor French: Monoamine oxidase
Entry term(s): Amine Oxidase (Flavin-Containing)
MAO
MAO A
MAO B
MAO-A
MAO-B
Monoamine Oxidase A
Monoamine Oxidase B
Oxidase, Monoamine
Oxidase, Tyramine
Type A Monoamine Oxidase
Type B Monoamine Oxidase
Tyramine Oxidase
Tree number(s): D08.811.682.664.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008995
Scope note: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Monoamine Oxidase Inhibitors
Registry Number: EC 1.4.3.4
CAS Type 1 Name: Amine:oxygen oxidoreductase (deaminating) (flavin-containing)
Public MeSH Note: 63; TYRAMINE OXIDASE was indexed under AMINE OXIDOREDUCTASES 1980-98
History Note: 63; for TYRAMINE OXIDASE use MONOAMINE OXIDASE (NM) 1980-98
DeCS ID: 9187
Unique ID: D008995
NLM Classification: QU 140
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1963/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/06/30
Monoamine Oxidase - Preferred
Concept UI M0014026
Scope note An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
Preferred term Monoamine Oxidase
Entry term(s) Amine Oxidase (Flavin-Containing)
MAO
Oxidase, Monoamine
Oxidase, Tyramine
Tyramine Oxidase
Type A Monoamine Oxidase - Narrower
Concept UI M0014027
Preferred term Type A Monoamine Oxidase
Entry term(s) MAO A
MAO-A
Monoamine Oxidase A
Monoamine Oxidase B - Narrower
Concept UI M0014028
Preferred term Monoamine Oxidase B
Entry term(s) MAO B
MAO-B
Type B Monoamine Oxidase



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