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Descriptor English: Antibody-Dependent Cell Cytotoxicity
Descriptor Spanish: Citotoxicidad Celular Dependiente de Anticuerpos
Descriptor citotoxicidad celular dependiente de anticuerpos
Entry term(s) ADCC
CCAD
citotoxicidad mediada por células dependientes de anticuerpos
Scope note: Fenómeno de destrucción celular mediado por anticuerpos por parte de células efectoras no sensibilizadas. La identidad de la célula destruida varía, pero debe tener en la superficie INMUNOGLOBULINA G cuya porción Fc esté intacta. La célula efectora es una célula citotóxica que posee receptores Fc. Puede ser un linfocito que carezca de los marcadores B o T convencionales, un monocito, un macrófago o un leucocito polimorfonuclear, dependiendo de la identidad de la célula a destruir. La reacción es independiente del complemento.
Descriptor Portuguese: Citotoxicidade Celular Dependente de Anticorpos
Descriptor French: Cytotoxicité à médiation cellulaire dépendante des anticorps
Entry term(s): ADCC
Antibody Dependent Cell Cytotoxicity
Antibody-Dependent Cell Cytotoxicities
Antibody-Dependent Cell Cytoxicities
Antibody-Dependent Cell Cytoxicity
Cell Cytotoxicities, Antibody-Dependent
Cell Cytotoxicity, Antibody-Dependent
Cell Cytoxicities, Antibody-Dependent
Cell Cytoxicity, Antibody Dependent
Cell Cytoxicity, Antibody-Dependent
Cytotoxicities, Antibody-Dependent Cell
Cytotoxicity, Antibody Dependent Cell
Cytotoxicity, Antibody-Dependent Cell
Cytoxicities, Antibody-Dependent Cell
Cytoxicity, Antibody-Dependent Cell
Tree number(s): G12.287.070
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000920
Scope note: The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Cytotoxicity Tests, Immunologic (1971-1977)
Immunity, Cellular (1970-1977)
Lymphocytes (1966-1977)
Public MeSH Note: 78
History Note: 78
Entry Version: ANTIBODY DEPENDENT CELL CYTOTOX
DeCS ID: 925
Unique ID: D000920
NLM Classification: QW 568
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1977/05/13
Revision Date: 2016/06/02
Antibody-Dependent Cell Cytotoxicity - Preferred
Concept UI M0001370
Scope note The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
Preferred term Antibody-Dependent Cell Cytotoxicity
Entry term(s) ADCC
Antibody Dependent Cell Cytotoxicity
Antibody-Dependent Cell Cytotoxicities
Antibody-Dependent Cell Cytoxicities
Antibody-Dependent Cell Cytoxicity
Cell Cytotoxicities, Antibody-Dependent
Cell Cytotoxicity, Antibody-Dependent
Cell Cytoxicities, Antibody-Dependent
Cell Cytoxicity, Antibody Dependent
Cell Cytoxicity, Antibody-Dependent
Cytotoxicities, Antibody-Dependent Cell
Cytotoxicity, Antibody Dependent Cell
Cytotoxicity, Antibody-Dependent Cell
Cytoxicities, Antibody-Dependent Cell
Cytoxicity, Antibody-Dependent Cell



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