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Descriptor English: Neurofibroma
Descriptor Spanish: Neurofibroma
Descriptor neurofibroma
Scope note: Tumor benigno, encapsulado, moderadamente firme, constituido por proliferación de CÉLULAS DE SCHWANN y FIBROBLASTOS que engloba partes de fibras nerviosas. Los tumores generalmente se desarrollan a lo largo de los nervios craneales o periféricos y son una característica central de la NEUROFIBROMATOSIS 1, en la que pueden aparecer intracranealmente o afectar a las raíces espinales. Las características patológicas comprenden el aumento de volumen fusiforme de los nervios afectados. El examen microscópico revela un patrón celular laxo desorganizado, con núcleos alargados entremezclados con bandas fibrosas. (Adams et al., Principles of Neurology, 6th ed, p1016)
Descriptor Portuguese: Neurofibroma
Descriptor French: Neurofibrome
Entry term(s): Neurofibromas
Tree number(s): C04.557.580.600.580
C10.551.775.500.750
C10.668.829.725.500.600
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009455
Scope note: A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)
Annotation: solitary; multiple = NEUROFIBROMATOSES but see MeSH definition; coord IM with precoord organ/neopl term (IM)
Allowable Qualifiers: BL blood
BS blood supply
CF cerebrospinal fluid
CH chemistry
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UL ultrastructure
UR urine
VE veterinary
VI virology
DeCS ID: 9647
Unique ID: D009455
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2009/07/06
Neurofibroma - Preferred
Concept UI M0014709
Scope note A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)
Preferred term Neurofibroma
Entry term(s) Neurofibromas



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