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Descriptor en español: beta-N-Acetilhexosaminidasas
Descriptor beta-N-acetilhexosaminidasas
Término(s) alternativo(s) beta-N-acetilhexosaminidasa
Nota de alcance: Hexosaminidasa específica de los residuos de N-acetil-D-hexosamina no reductores de las N-acetil-beta-D-hexosaminidas. Actúa sobre GLUCÓSIDOS, GALACTÓSIDOS y algunos OLIGOSACÁRIDOS. La HEXOSAMINIDASA A y la HEXOSAMINIDASA B son dos isoenzimas de la beta-N-acetilhexoaminidasa específicas de los mamíferos. La deficiencia de la isoenzima A causa la ENFERMEDAD DE TAY-SACHS, mientras que la deficiencia de las isoenzimas A y B da lugar a la ENFERMEDAD DE SANDHOFF. La enzima también se ha utilizado como marcador tumoral para distinguir las neoplasias malignas y benignas.
Descriptor en inglés: beta-N-Acetylhexosaminidases
Descriptor en portugués: beta-N-Acetil-Hexosaminidases
Descriptor en francés: beta-N-Acetylhexosaminidases
Término(s) alternativo(s): N Acetyl beta D hexosaminidase
N-Acetyl-beta-D-hexosaminidase
beta Hexosaminidase
beta N Acetyl D hexosaminidase
beta N Acetyl hexosaminidase
beta N Acetylhexosaminidase
beta N Acetylhexosaminidases
beta-Hexosaminidase
beta-N-Acetyl-D-hexosaminidase
beta-N-Acetyl-hexosaminidase
beta-N-Acetylhexosaminidase
Código(s) jeráquico(s): D08.811.277.450.483.180
Identificador Único RDF: https://id.nlm.nih.gov/mesh/D001619
Nota de alcance: A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
Nota de indización: do not confuse with ACETYLGLUCOSAMINIDASE; /defic: consider also TAY SACHS DISEASE and SANDHOFF DISEASE
Calificadores permitidos: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Número de registro: EC 3.2.1.52
Nombre CAS Tipo 1: beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase
Indexación anterior: Glycoside Hydrolases (1966-1970)
Hexosaminidases (1971-1986)
Nota Pública de MeSH: 2008; see BETA-N-ACETYL-D-HEXOSAMINIDASE 1988-2007
Nota de historia: 2008(1988)
Vea también los descriptores: Sandhoff Disease MeSH
Tay-Sachs Disease MeSH
Identificador de DeCS: 19087
ID del Descriptor: D001619
Documentos indizados en la Biblioteca Virtual de Salud (BVS): Haga clic aquí para acceder a los documentos de la BVS
Fecha de establecimiento: 01/01/1987
Fecha de entrada: 02/06/1986
Fecha de revisión: 09/07/2007
beta-N-Acetylhexosaminidases - Concepto preferido
UI del concepto M0002423
Nota de alcance A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
Término preferido beta-N-Acetylhexosaminidases
Término(s) alternativo(s) N Acetyl beta D hexosaminidase
N-Acetyl-beta-D-hexosaminidase
beta Hexosaminidase
beta N Acetyl D hexosaminidase
beta N Acetyl hexosaminidase
beta N Acetylhexosaminidase
beta N Acetylhexosaminidases
beta-Hexosaminidase
beta-N-Acetyl-D-hexosaminidase
beta-N-Acetyl-hexosaminidase
beta-N-Acetylhexosaminidase



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