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| Descriptor en español: |
Proteínas de Neurofilamentos
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| Descriptor en inglés: | Neurofilament Proteins | ||||||
| Descriptor en portugués: | Proteínas de Neurofilamentos | ||||||
| Descriptor en francés: | Protéines neurofilamenteuses | ||||||
| Término(s) alternativo(s): |
Heavy Neurofilament Protein Neurofilament Protein Neurofilament Protein, Heavy Neurofilament Triplet Proteins Protein, Heavy Neurofilament Protein, Neurofilament Proteins, Neurofilament Proteins, Neurofilament Triplet Triplet Proteins, Neurofilament |
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| Código(s) jeráquico(s): |
D05.750.078.593.630 D12.776.220.475.630 D12.776.631.630 |
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| Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D016900 | ||||||
| Nota de alcance: | Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302) |
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| Nota de indización: | /biosyn /physiol permitted |
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| Calificadores permitidos: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Indexación anterior: |
Intermediate Filament Proteins (1982-1991) Nerve Tissue Proteins (1970-1982) |
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| Nota Pública de MeSH: | 92; NEUROFILAMENT PROTEINS was indexed under INTERMEDIATE FILAMENT PROTEINS 1982-91 & NERVE TISSUE PROTEINS 1977-82 |
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| Nota Online: | use NEUROFILAMENT PROTEINS (NM) to search NEUROFILAMENT PROTEINS 1977-91 |
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| Nota de historia: | 92; was NEUROFILAMENT PROTEINS (NM) 1977-91 |
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| Identificador de DeCS: | 29931 | ||||||
| ID del Descriptor: | D016900 | ||||||
| Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
| Fecha de establecimiento: | 01/01/1992 | ||||||
| Fecha de entrada: | 30/05/1991 | ||||||
| Fecha de revisión: | 17/06/2020 |
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CHEMICALS AND DRUGS
Macromolecular Substances [D05]Macromolecular Substances -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Neurofilament Proteins
- Concepto preferido
Neurofilament Triplet Proteins
- Más estrecho
Heavy Neurofilament Protein
- Más estrecho
| UI del concepto |
M0025716 |
| Nota de alcance | Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302) |
| Término preferido | Neurofilament Proteins |
| Término(s) alternativo(s) |
Neurofilament Protein Protein, Neurofilament Proteins, Neurofilament |
| UI del concepto |
M0025718 |
| Término preferido | Neurofilament Triplet Proteins |
| Término(s) alternativo(s) |
Proteins, Neurofilament Triplet Triplet Proteins, Neurofilament |
| UI del concepto |
M0025717 |
| Término preferido | Heavy Neurofilament Protein |
| Término(s) alternativo(s) |
Neurofilament Protein, Heavy Protein, Heavy Neurofilament |
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