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Descriptor en español: |
Proteínas MutL
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Descriptor en inglés: | MutL Proteins | ||||||
Descriptor en portugués: | Proteínas MutL | ||||||
Descriptor en francés: | Protéines MutL | ||||||
Término(s) alternativo(s): |
MutL Homologs |
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Código(s) jeráquico(s): |
D08.811.074.766 D08.811.277.040.025.215 D12.776.260.540 |
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Identificador Único RDF: | https://id.nlm.nih.gov/mesh/D000070956 | ||||||
Nota de alcance: | DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA. |
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Calificadores permitidos: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Número de registro: | EC 3.6.1.3 | ||||||
Indexación anterior: |
Adenosine Triphosphatases (1992-2016) DNA Repair (1982-2016) |
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Nota Pública de MeSH: | 2017 |
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Nota de historia: | 2017 |
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Identificador de DeCS: | 56465 | ||||||
ID del Descriptor: | D000070956 | ||||||
Documentos indizados en la Biblioteca Virtual de Salud (BVS): | Haga clic aquí para acceder a los documentos de la BVS | ||||||
Fecha de establecimiento: | 01/01/2017 | ||||||
Fecha de entrada: | 08/07/2016 | ||||||
Fecha de revisión: | 26/02/2016 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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MutL Proteins
- Concepto preferido
MutL Homologs
- Más estrecho
UI del concepto |
M000612744 |
Nota de alcance | DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA. |
Término preferido | MutL Proteins |
UI del concepto |
M000612745 |
Término preferido | MutL Homologs |
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