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Descripteur en français: Diversité des anticorps
Descripteur en anglais: Antibody Diversity
Descripteur en espagnol: Diversidad de Anticuerpos
Descripteur en portugais: Diversidade de Anticorpos
Synonymes: Théorie de la lignée germinale
Code(s) d'arborescence: G05.365.036
G12.500.199
Identificateur unique RDF: https://id.nlm.nih.gov/mesh/D000916
Note d'application: The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
Qualificatifs autorisés: DE effets des médicaments et des substances chimiques
GE génétique
IM immunologie
PH physiologie
RE effets des radiations
Identifiant DeCS: 926
ID du Descripteur: D000916
Documents indexés dans la Biblioteque Virtuelle de Santé (BVS): Cliquez ici pour accéder aux documents VHL
Date d'établissement: 01/01/1980
Date d'entrée: 23/02/1979
Date de révision: 22/06/2015
Diversité des anticorps - Concept préféré
Concept UI M0001364
Terme préféré Diversité des anticorps
Théorie de la lignée germinale - Plus spécifique
Concept UI M0001365
Terme préféré Théorie de la lignée germinale



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