DeCS

Descritor em português:

Sinapsinas

Descritor em inglês:

Synapsins

Descritor em espanhol:

Sinapsinas

Espanhol da Espanha

Descritor	sinapsinas
Termo(s) alternativo(s)	sinapsina sinapsina I sinapsina II sinapsina III
Nota de escopo:	Familia de proteínas asociadas a las vesículas sinápticas, que participan en la regulación a corto plazo de la liberación de NEUROTRANSMISORES. La sinapsina I, miembro predominante de esta familia, une las VESICULAS SINÁPTICAS a los FILAMENTOS DE ACTINA en la terminal nerviosa presináptica. Estas interacciones son moduladas por la FOSFORILACIÓN reversible de la sinapsina I por medio de varias vías de señales de transducción. La proteína también es un sustrato para cAMP y las PROTEINA QUINASA DEPENDIENTE DE CA(2+)-CALMODULINA. Se cree que estas propiedades funcionales son compartidas también por la sinapsina II.

Descritor em francês:

Synapsine

Termo(s) alternativo(s):

Synapsin
Synapsin I
Synapsin II
Synapsin III

Código(s) hierárquico(s):

D12.776.631.750
D12.776.744.840

Identificador Único RDF:

https://id.nlm.nih.gov/mesh/D016704

Nota de escopo:

A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.

Qualificadores permitidos:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Identificador do conceito	M0025442
Nota de escopo	A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
Termo preferido	Synapsins
Termo(s) alternativo(s)	Synapsin

Identificador do conceito	M0025445
Termo preferido	Synapsin II

Identificador do conceito	M0025443
Termo preferido	Synapsin III

Identificador do conceito	M0025444
Termo preferido	Synapsin I

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