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Descriptor English: Oxamniquine
Descriptor Spanish: Oxamniquina
Descriptor oxamniquina
Scope note: Antihelmíntico con actividad frente al Schistosoma mansoni, pero no frente a otras Schistosoma spp. La oxamniquina hace que los gusanos emigren desde las venas mesentéricas al hígado, donde son retenidas las formas masculinas; el gusano hembra regresa al mesenterio, pero no puede ya liberar huevos. (Martidale, The Extra Pharmacopoeia, 31st ed, p121).
Descriptor Portuguese: Oxamniquine
Descriptor French: Oxamniquine
Entry term(s): Oxaminiquine
UK 4271
UK-4271
UK4271
Tree number(s): D03.633.100.810.350.600
D03.633.100.810.470.600
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010073
Scope note: An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Schistosomicides
Registry Number: 0O977R722D
CAS Type 1 Name: 6-Quinolinemethanol, 1,2,3,4-tetrahydro-2-(((1-methylethyl)amino)methyl)-7-nitro-
Previous Indexing: Nitro Compounds (1973-1974)
Propylamines (1973-1974)
Quinolines (1973-1974)
Public MeSH Note: 91; was see under NITROQUINOLINES 1975-90
History Note: 91(75); was see under NITROQUINOLINES 1975-90
DeCS ID: 10249
Unique ID: D010073
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/05/31
Oxamniquine - Preferred
Concept UI M0015634
Scope note An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)
Preferred term Oxamniquine
Entry term(s) Oxaminiquine
UK-4271 - Narrower
Concept UI M0353874
Preferred term UK-4271
Entry term(s) UK 4271
UK4271



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