| Descriptor English: | Phenobarbital |
| Descriptor Spanish: | Fenobarbital |
| Descriptor Portuguese: | Fenobarbital |
| Descriptor French: | Phénobarbital |
| Entry term(s): |
Acid, Phenylethylbarbituric Gardenal Hysteps Luminal Monosodium Salt Phenobarbital Phenemal Phenobarbital Sodium Phenobarbital, Monosodium Salt Phenobarbitone Phenylbarbital Phenylethylbarbituric Acid Sodium, Phenobarbital |
| Tree number(s): |
D03.383.742.698.253.650 |
| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D010634 |
| Scope note: | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. |
| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
| Pharm Action: |
Anticonvulsants Hypnotics and Sedatives Excitatory Amino Acid Antagonists GABA Modulators Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP3A Inducers |
| Registry Number: | YQE403BP4D |
| CAS Type 1 Name: | 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl- |
| DeCS ID: | 10826 |
| Unique ID: | D010634 |
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents |
| Date Established: | 1966/01/01 |
| Date of Entry: | 1999/01/01 |
| Revision Date: | 2016/05/31 |
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CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds
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Phenobarbital
- Preferred
Hysteps
- Narrower
Phenobarbital Sodium
- Narrower
Luminal
- Narrower
Gardenal
- Narrower
| Concept UI |
M0016514 |
| Scope note | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. |
| Preferred term | Phenobarbital |
| Entry term(s) |
Acid, Phenylethylbarbituric Phenemal Phenobarbitone Phenylbarbital Phenylethylbarbituric Acid |
| Concept UI |
M0016517 |
| Preferred term | Hysteps |
| Concept UI |
M0331275 |
| Preferred term | Phenobarbital Sodium |
| Entry term(s) |
Monosodium Salt Phenobarbital Phenobarbital, Monosodium Salt Sodium, Phenobarbital |
| Concept UI |
M0016518 |
| Preferred term | Luminal |
| Concept UI |
M0016516 |
| Preferred term | Gardenal |
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