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Descriptor English: Phenobarbital
Descriptor Spanish: Fenobarbital
Descriptor fenobarbital
Entry term(s) fenemal
fenilbarbital
fenobarbitona
Scope note: Derivado del ácido barbitúrico que actúa como depresor no selectivo del sistema nervioso central. Potencia la acción del ÁCIDO GAMMA-AMINOBUTÍRICO sobre los RECEPTORES DE GABA A y modula las corrientes de cloruro a través de los canales del receptor. Inhibe, también, la despolarización inducida por glutamato.
Descriptor Portuguese: Fenobarbital
Descriptor French: Phénobarbital
Entry term(s): Acid, Phenylethylbarbituric
Gardenal
Hysteps
Luminal
Monosodium Salt Phenobarbital
Phenemal
Phenobarbital Sodium
Phenobarbital, Monosodium Salt
Phenobarbitone
Phenylbarbital
Phenylethylbarbituric Acid
Sodium, Phenobarbital
Tree number(s): D03.383.742.698.253.650
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010634
Scope note: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticonvulsants
Hypnotics and Sedatives
Excitatory Amino Acid Antagonists
GABA Modulators
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 CYP3A Inducers
Registry Number: YQE403BP4D
CAS Type 1 Name: 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-
DeCS ID: 10826
Unique ID: D010634
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Phenobarbital - Preferred
Concept UI M0016514
Scope note A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Preferred term Phenobarbital
Entry term(s) Acid, Phenylethylbarbituric
Phenemal
Phenobarbitone
Phenylbarbital
Phenylethylbarbituric Acid
Hysteps - Narrower
Concept UI M0016517
Preferred term Hysteps
Phenobarbital Sodium - Narrower
Concept UI M0331275
Preferred term Phenobarbital Sodium
Entry term(s) Monosodium Salt Phenobarbital
Phenobarbital, Monosodium Salt
Sodium, Phenobarbital
Luminal - Narrower
Concept UI M0016518
Preferred term Luminal
Gardenal - Narrower
Concept UI M0016516
Preferred term Gardenal



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