DeCS

Descriptor English:

Phenobarbital

Descriptor Spanish:

Fenobarbital

Spanish from Spain

Descriptor	fenobarbital
Entry term(s)	fenemal fenilbarbital fenobarbitona
Scope note:	Derivado del ácido barbitúrico que actúa como depresor no selectivo del sistema nervioso central. Potencia la acción del ÁCIDO GAMMA-AMINOBUTÍRICO sobre los RECEPTORES DE GABA A y modula las corrientes de cloruro a través de los canales del receptor. Inhibe, también, la despolarización inducida por glutamato.

Descriptor Portuguese:

Fenobarbital

Descriptor French:

Phénobarbital

Entry term(s):

Phénobarbital de sodium
Phénobarbital sodique

Tree number(s):

D03.383.742.698.253.650

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D010634

Scope note:

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Anticonvulsants
Hypnotics and Sedatives
Excitatory Amino Acid Antagonists
GABA Modulators
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 CYP3A Inducers

Registry Number:

YQE403BP4D

CAS Type 1 Name:

2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-

DeCS ID:

10826

Unique ID:

D010634

NLM Classification:

QV 88

Documents indexed in the Virtual Health Library (VHL):

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