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Descriptor English: Polymyxin B
Descriptor Spanish: Polimixina B
Descriptor polimixina B
Scope note: Mezcla de polimixinas B1 y B2, obtenidas de cepas de BACILLUS POLYMYXA. Son polipéptidos básicos de unos ocho aminoácidos y tienen acción detergente catiónica sobre las membranas celulares. La polimixina B se utiliza en el tratamiento de infecciones por bacterias gramnegativas, pero puede ser neurotóxica y nefrotóxica.
Descriptor Portuguese: Polimixina B
Descriptor French: Polymyxine B
Entry term(s): Aerosporin
Polymyxin B Sulfate
Tree number(s): D04.345.566.780.750
D10.477.750.750
D12.644.050.600.750
D12.644.066.500.600.750
D12.644.641.780.750
D12.776.543.695.054.600.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011112
Scope note: A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Registry Number: J2VZ07J96K
CAS Type 1 Name: Polymyxin B
Public MeSH Note: 1991; was see under POLYMYXINS 1978-90; was AEROSPORIN see under POLYMYXIN 1971-77, see POLYMYXIN 1963-70; AEROSPORIN was see POLYMYXIN B 1978-93
Online Note: use POLYMYXIN B to search AEROSPORIN 1975-93; use POLYMYXINS 1966-74
History Note: 1991(1978); was see under POLYMYXINS 1978-90; was AEROSPORIN see under POLYMYXIN 1971-77, see POLYMYXIN 1963-70; AEROSPORIN was see POLYMYXIN B 1978-93
DeCS ID: 11549
Unique ID: D011112
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/05/21
Polymyxin B - Preferred
Concept UI M0017214
Scope note A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.
Preferred term Polymyxin B
Polymyxin B Sulfate - Related but not broader or narrower
Concept UI M0017213
Preferred term Polymyxin B Sulfate
Aerosporin - Narrower
Concept UI M0017215
Preferred term Aerosporin



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