Search
Descriptor English: Pore Forming Cytotoxic Proteins
Descriptor Spanish: Proteínas Citotóxicas Formadoras de Poros
Descriptor proteínas citotóxicas formadoras de poros
Scope note: Proteínas segregadas por un organismo, que forman poros que se extienden por la membrana en las células diana para destruirlas. Este hecho contrasta con las PORINAS y las PROTEÍNAS TRANSPORTADORAS DE LA MEMBRANA, que funcionan en el interior del organismo sintetizador y las proteínas inmunitarias del COMPLEMENTO. Estas proteínas citotóxicas formadoras de poros son una forma de defensa celular primitiva que se encuentran también en los LINFOCITOS humanos.
Descriptor Portuguese: Proteínas Citotóxicas Formadoras de Poros
Descriptor French: Perforines
Tree number(s): D12.776.543.695
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D052899
Scope note: Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Porins (1980-2006)
Public MeSH Note: 2007
History Note: 2007
Related: Porins MeSH
DeCS ID: 52332
Unique ID: D052899
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2020/01/16
Pore Forming Cytotoxic Proteins - Preferred
Concept UI M0490137
Scope note Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
Preferred term Pore Forming Cytotoxic Proteins



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey