| Descriptor English: | Farnesyl-Diphosphate Farnesyltransferase | ||||||
| Descriptor Spanish: |
Farnesil Difosfato Farnesil Transferasa
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| Descriptor Portuguese: | Farnesil-Difosfato Farnesiltransferase | ||||||
| Descriptor French: | Farnesyl-diphosphate farnesyltransferase | ||||||
| Entry term(s): |
FPP FPP Farnesyl Transferase FPP-FPP Farnesyl Transferase Farnesyl Diphosphate Farnesyltransferase Farnesyl Transferase, FPP-FPP Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase Farnesyltransferase, Farnesyl-Diphosphate Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate Presqualene Diphosphate Synthase Presqualene-Diphosphate Synthase Squalene Synthase Squalene Synthetase Synthase, Presqualene-Diphosphate Synthase, Squalene Synthetase, Squalene Transferase, FPP-FPP Farnesyl |
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| Tree number(s): |
D08.811.913.225.431 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D013186 | ||||||
| Scope note: | The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.5.1.21 | ||||||
| Previous Indexing: |
Farnesol (1972-1974) Ligases (1972-1974) Pyrophosphoric Acids (1972-1974) Squalene (1972-1974) |
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| Public MeSH Note: | 2006; see OXIDOREDUCTASES 1975-1990; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE was indexed under OXIDOREDUCTASES & SQUALENE SYNTHETASE 1998-2001 |
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| History Note: | 2006(1975) |
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| DeCS ID: | 13571 | ||||||
| Unique ID: | D013186 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1974/11/19 | ||||||
| Revision Date: | 2009/07/13 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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Farnesyl-Diphosphate Farnesyltransferase
- Preferred
| Concept UI |
M0020401 |
| Scope note | The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway. |
| Preferred term | Farnesyl-Diphosphate Farnesyltransferase |
| Entry term(s) |
FPP FPP Farnesyl Transferase FPP-FPP Farnesyl Transferase Farnesyl Diphosphate Farnesyltransferase Farnesyl Transferase, FPP-FPP Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase Farnesyltransferase, Farnesyl-Diphosphate Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate Presqualene Diphosphate Synthase Presqualene-Diphosphate Synthase Squalene Synthase Squalene Synthetase Synthase, Presqualene-Diphosphate Synthase, Squalene Synthetase, Squalene Transferase, FPP-FPP Farnesyl |
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