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Descriptor English: Tacrine
Descriptor Spanish: Tacrina
Descriptor Portuguese: Tacrina
Descriptor French: Tacrine
Entry term(s): 1,2,3,4-Tetrahydro-9-acridinamine
1,2,3,4-Tetrahydroaminoacridine
9-Amino-1,2,3,4-Tetrahydroacridine
Cognex
Romotal
THA
Tacrine Hydrochloride
Tenakrin
Tetrahydroaminoacridine
Tree number(s): D03.633.300.046.250.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013619
Scope note: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Cholinesterase Inhibitors
Parasympathomimetics
Nootropic Agents
Registry Number: 4VX7YNB537
CAS Type 1 Name: 9-Acridinamine, 1,2,3,4-tetrahydro-
Previous Indexing: Acridines (1969-1974)
Amines (1972-1974)
Public MeSH Note: 91; was see under AMINOACRIDINES 1984-90; was see under ACRIDINES 1975-83
History Note: 91(75); was see under AMINOACRIDINES 1984-90; was see under ACRIDINES 1975-83
DeCS ID: 13996
Unique ID: D013619
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2017/05/24
Tacrine - Preferred
Concept UI M0021008
Scope note A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
Preferred term Tacrine
Entry term(s) 1,2,3,4-Tetrahydro-9-acridinamine
1,2,3,4-Tetrahydroaminoacridine
9-Amino-1,2,3,4-Tetrahydroacridine
Tetrahydroaminoacridine
Romotal - Narrower
Concept UI M0021009
Preferred term Romotal
Tenakrin - Narrower
Concept UI M0332604
Preferred term Tenakrin
THA - Narrower
Concept UI M0476031
Preferred term THA
Cognex - Narrower
Concept UI M0021010
Preferred term Cognex
Tacrine Hydrochloride - Narrower
Concept UI M0021011
Preferred term Tacrine Hydrochloride



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