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Descriptor English: Teniposide
Descriptor Spanish: Tenipósido
Descriptor tenipósido
Entry term(s) VM-26
desmetil epipodofilotoxina tenilidina glucósido
Scope note: Derivado semi-sintético de la PODOFILOTOXINA con actividad antitumoral. El tenipósido inhibe la síntesis de ADN mediante la formación de un complejo con la topoisomerasa II y el ADN. Este complejo induce rupturas en el ADN de cadena doble e impide su reparación por unión con la topoisomerasa II. Las roturas acumuladas del ADN impiden que las células entren en la fase mitótica del ciclo celular dando lugar a la muerte de la célula. El tenipósido actúa principalmente en las fases G2 y S del ciclo celular.
Descriptor Portuguese: Teniposídeo
Descriptor French: Téniposide
Entry term(s): Demethyl Epipodophyllotoxin Thenylidine Glucoside
NSC 122819
NSC-122819
NSC122819
Teniposide, (5a alpha,9 alpha(S*))-Isomer
VM 26
VM-26
VM26
Vumon
Tree number(s): D09.408.348.800
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013713
Scope note: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Topoisomerase II Inhibitors
Registry Number: 957E6438QA
CAS Type 1 Name: Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
Previous Indexing: Glucosides (1975)
Glycosides (1973-1974)
Podophyllotoxin (1973-1974)
Public MeSH Note: 91; was see under PODOPHYLLOTOXIN 1981-90; was VM 26 see under PODOPHYLLOTOXIN 1976-80
Online Note: use TENIPOSIDE to search VM 26 1976-80
History Note: 91(81); was see under PODOPHYLLOTOXIN 1981-90; was VM 26 see under PODOPHYLLOTOXIN 1976-80
DeCS ID: 14091
Unique ID: D013713
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1975/07/25
Revision Date: 2016/07/01
Teniposide - Preferred
Concept UI M0021161
Scope note A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Preferred term Teniposide
Entry term(s) Demethyl Epipodophyllotoxin Thenylidine Glucoside
Vumon - Narrower
Concept UI M0357357
Preferred term Vumon
VM-26 - Narrower
Concept UI M0357358
Preferred term VM-26
Entry term(s) VM 26
VM26
Teniposide, (5a alpha,9 alpha(S*))-Isomer - Related but not broader or narrower
Concept UI M0329641
Preferred term Teniposide, (5a alpha,9 alpha(S*))-Isomer
NSC-122819 - Narrower
Concept UI M0357359
Preferred term NSC-122819
Entry term(s) NSC 122819
NSC122819



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