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Descriptor English: Etoposide
Descriptor Spanish: Etopósido
Descriptor etopósido
Entry term(s) glucósido de demetil epipodofilotoxina etilidina
Scope note: Derivado semisintético de la PODOFILOTOXINA que muestra actividad antitumoral. El etopósido inhibide la síntesis de ADN al formar un complejo con la tipoisomerasa II y el ADN. Este complejo induce roturas en el ADN de doble cadena y previene la reparación por la unión a la topoisomerasa II. Las roturas de ADN acumuladas previenen la entrada en la fase de mitosis de la división celular y llevan a la muerte celular. El etopósido actúa principalmente en las fases G2 y S del ciclo celular.
Descriptor Portuguese: Etoposídeo
Descriptor French: Étoposide
Entry term(s): Celltop
Demethyl Epipodophyllotoxin Ethylidine Glucoside
Eposide
Eposin
Eto GRY
Eto-GRY
Etomedac
Etopos
Etoposide Pierre Fabre
Etoposide Teva
Etoposide, (5S)-Isomer
Etoposide, (5a alpha)-Isomer
Etoposide, (5a alpha,9 alpha)-Isomer
Etoposide, alpha D Glucopyranosyl Isomer
Etoposide, alpha-D-Glucopyranosyl Isomer
Etoposido Ferrer Farma
Exitop
Lastet
NSC 141540
NSC-141540
NSC141540
Onkoposid
Riboposid
Teva, Etoposide
Toposar
VP 16
VP 16 213
VP 16-213
VP 16213
VP-16
VP16
Vepesid
Vépéside Sandoz
Vépéside-Sandoz
alpha-D-Glucopyranosyl Isomer Etoposide
Tree number(s): D02.455.426.559.847.638.960.675.250
D04.615.638.960.675.250
D09.408.348.275
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005047
Scope note: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Phytogenic
Topoisomerase II Inhibitors
Registry Number: 6PLQ3CP4P3
CAS Type 1 Name: Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
Previous Indexing: Glucosides (1975)
Glycosides (1973-1974)
Podophyllotoxin (1973-1974)/analogs & derivatives (1975)
Public MeSH Note: 87; was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
Online Note: use ETOPOSIDE to search VP 16-213 1976-80
History Note: 87(81); was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
DeCS ID: 5143
Unique ID: D005047
NLM Classification: QV 269
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1975/07/25
Revision Date: 2018/03/01
Etoposide - Preferred
Concept UI M0007930
Scope note A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Preferred term Etoposide
Entry term(s) Demethyl Epipodophyllotoxin Ethylidine Glucoside
Eposide
Eto-GRY - Narrower
Concept UI M0478088
Preferred term Eto-GRY
Entry term(s) Eto GRY
Etoposide, (5a alpha,9 alpha)-Isomer - Narrower
Concept UI M0330376
Preferred term Etoposide, (5a alpha,9 alpha)-Isomer
Etoposide, (5S)-Isomer - Narrower
Concept UI M0330374
Preferred term Etoposide, (5S)-Isomer
Etoposide, alpha-D-Glucopyranosyl Isomer - Narrower
Concept UI M0330373
Preferred term Etoposide, alpha-D-Glucopyranosyl Isomer
Entry term(s) Etoposide, alpha D Glucopyranosyl Isomer
alpha-D-Glucopyranosyl Isomer Etoposide
Etoposido Ferrer Farma - Narrower
Concept UI M0478091
Preferred term Etoposido Ferrer Farma
Exitop - Narrower
Concept UI M0478093
Preferred term Exitop
Lastet - Narrower
Concept UI M0478094
Preferred term Lastet
NSC-141540 - Narrower
Concept UI M0350940
Preferred term NSC-141540
Entry term(s) NSC 141540
NSC141540
Onkoposid - Narrower
Concept UI M0478095
Preferred term Onkoposid
Riboposid - Narrower
Concept UI M0478096
Preferred term Riboposid
Toposar - Narrower
Concept UI M0478087
Preferred term Toposar
Entry term(s) Etoposide Teva
Teva, Etoposide
Vepesid - Narrower
Concept UI M0007931
Preferred term Vepesid
VP 16-213 - Narrower
Concept UI M0350945
Preferred term VP 16-213
Entry term(s) VP 16 213
VP 16213
VP-16 - Narrower
Concept UI M0350960
Preferred term VP-16
Entry term(s) VP 16
VP16
Vépéside-Sandoz - Narrower
Concept UI M0478097
Preferred term Vépéside-Sandoz
Entry term(s) Vépéside Sandoz
Celltop - Narrower
Concept UI M0478085
Preferred term Celltop
Etopos - Narrower
Concept UI M0478092
Preferred term Etopos
Etomedac - Narrower
Concept UI M000638458
Preferred term Etomedac
Eposin - Narrower
Concept UI M0478086
Preferred term Eposin
Etoposide, (5a alpha)-Isomer - Narrower
Concept UI M0330375
Preferred term Etoposide, (5a alpha)-Isomer
Etoposide Pierre Fabre - Narrower
Concept UI M0478089
Preferred term Etoposide Pierre Fabre



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