| Descriptor English: | Uroporphyrinogen III Synthetase | ||||||
| Descriptor Spanish: |
Uroporfirinógeno III Sintetasa
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| Descriptor Portuguese: | Uroporfirinogênio III Sintetase | ||||||
| Descriptor French: | Uroporphyrinogen III synthetase | ||||||
| Entry term(s): |
Cosynthase Cosynthetase, Uroporphyrinogen III Isomerase, Uroporphyrinogen Synthase, Uroporphyrinogen-III Synthetase, Uroporphyrinogen III Uroporphyrinogen III Cosynthetase Uroporphyrinogen III Synthase Uroporphyrinogen Isomerase Uroporphyrinogen-III Synthase |
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| Tree number(s): |
D08.811.520.241.300.950 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D014576 | ||||||
| Scope note: | An enzyme that catalyzes the cyclization of hydroxymethylbilane to yield UROPORPHYRINOGEN III and water. It is the fourth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by UROS gene. Mutations of UROS gene result in CONGENITAL ERYTHROPOIETIC PORPHYRIA. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Entry Combination: |
deficiency:Porphyria, Erythropoietic
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| Registry Number: | EC 4.2.1.75 | ||||||
| CAS Type 1 Name: | Hydroxymethylbilane hydro-lyase (cyclizing) | ||||||
| Previous Indexing: |
Isomerases (1971-1974) Porphobilinogen (1973-1974) |
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| Public MeSH Note: | 2005; see UROPORPHYRINOGEN-III SYNTHASE 1998-2004, see UROPORPHYRINOGEN III SYNTHASE 1991-1997, see HYDRO-LYASES 1985-1990, see ISOMERASES 1975-1984 |
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| History Note: | 2005 (1975) |
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| Related: |
Porphyria, Erythropoietic
MeSH | ||||||
| DeCS ID: | 14978 | ||||||
| Unique ID: | D014576 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1974/11/19 | ||||||
| Revision Date: | 2009/07/06 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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Uroporphyrinogen III Synthetase
- Preferred
| Concept UI |
M0022407 |
| Scope note | An enzyme that catalyzes the cyclization of hydroxymethylbilane to yield UROPORPHYRINOGEN III and water. It is the fourth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by UROS gene. Mutations of UROS gene result in CONGENITAL ERYTHROPOIETIC PORPHYRIA. |
| Preferred term | Uroporphyrinogen III Synthetase |
| Entry term(s) |
Cosynthase Cosynthetase, Uroporphyrinogen III Isomerase, Uroporphyrinogen Synthase, Uroporphyrinogen-III Synthetase, Uroporphyrinogen III Uroporphyrinogen III Cosynthetase Uroporphyrinogen III Synthase Uroporphyrinogen Isomerase Uroporphyrinogen-III Synthase |
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