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Descriptor English: beta-N-Acetylhexosaminidases
Descriptor Spanish: beta-N-Acetilhexosaminidasas
Descriptor beta-N-acetilhexosaminidasas
Entry term(s) beta-N-acetilhexosaminidasa
Scope note: Hexosaminidasa específica de los residuos de N-acetil-D-hexosamina no reductores de las N-acetil-beta-D-hexosaminidas. Actúa sobre GLUCÓSIDOS, GALACTÓSIDOS y algunos OLIGOSACÁRIDOS. La HEXOSAMINIDASA A y la HEXOSAMINIDASA B son dos isoenzimas de la beta-N-acetilhexoaminidasa específicas de los mamíferos. La deficiencia de la isoenzima A causa la ENFERMEDAD DE TAY-SACHS, mientras que la deficiencia de las isoenzimas A y B da lugar a la ENFERMEDAD DE SANDHOFF. La enzima también se ha utilizado como marcador tumoral para distinguir las neoplasias malignas y benignas.
Descriptor Portuguese: beta-N-Acetil-Hexosaminidases
Descriptor French: beta-N-Acetylhexosaminidases
Entry term(s): N-Acétyl-bêta-D-hexosaminidase
beta-Hexosaminidase
beta-N-Acetyl-hexosaminidase
beta-N-Acetylhexosaminidase
Tree number(s): D08.811.277.450.483.180
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001619
Scope note: A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
Annotation: do not confuse with ACETYLGLUCOSAMINIDASE; /defic: consider also TAY SACHS DISEASE and SANDHOFF DISEASE
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Registry Number: EC 3.2.1.52
CAS Type 1 Name: beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase
Related: Maladie de Sandhoff MeSH
Maladie de Tay-Sachs MeSH
DeCS ID: 19087
Unique ID: D001619
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/02
Revision Date: 2007/07/09
beta-N-Acetylhexosaminidases - Preferred
Concept UI M0002423
Preferred term beta-N-Acetylhexosaminidases
Entry term(s) N-Acétyl-bêta-D-hexosaminidase
beta-Hexosaminidase
beta-N-Acetyl-hexosaminidase
beta-N-Acetylhexosaminidase



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