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Descriptor English: beta-N-Acetylhexosaminidases
Descriptor Spanish: beta-N-Acetilhexosaminidasas
Descriptor beta-N-acetilhexosaminidasas
Entry term(s) beta-N-acetilhexosaminidasa
Scope note: Hexosaminidasa específica de los residuos de N-acetil-D-hexosamina no reductores de las N-acetil-beta-D-hexosaminidas. Actúa sobre GLUCÓSIDOS, GALACTÓSIDOS y algunos OLIGOSACÁRIDOS. La HEXOSAMINIDASA A y la HEXOSAMINIDASA B son dos isoenzimas de la beta-N-acetilhexoaminidasa específicas de los mamíferos. La deficiencia de la isoenzima A causa la ENFERMEDAD DE TAY-SACHS, mientras que la deficiencia de las isoenzimas A y B da lugar a la ENFERMEDAD DE SANDHOFF. La enzima también se ha utilizado como marcador tumoral para distinguir las neoplasias malignas y benignas.
Descriptor Portuguese: beta-N-Acetil-Hexosaminidases
Descriptor French: beta-N-Acetylhexosaminidases
Entry term(s): N Acetyl beta D hexosaminidase
N-Acetyl-beta-D-hexosaminidase
beta Hexosaminidase
beta N Acetyl D hexosaminidase
beta N Acetyl hexosaminidase
beta N Acetylhexosaminidase
beta N Acetylhexosaminidases
beta-Hexosaminidase
beta-N-Acetyl-D-hexosaminidase
beta-N-Acetyl-hexosaminidase
beta-N-Acetylhexosaminidase
Tree number(s): D08.811.277.450.483.180
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001619
Scope note: A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
Annotation: do not confuse with ACETYLGLUCOSAMINIDASE; /defic: consider also TAY SACHS DISEASE and SANDHOFF DISEASE
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.2.1.52
CAS Type 1 Name: beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase
Previous Indexing: Glycoside Hydrolases (1966-1970)
Hexosaminidases (1971-1986)
Public MeSH Note: 2008; see BETA-N-ACETYL-D-HEXOSAMINIDASE 1988-2007
History Note: 2008(1988)
Related: Sandhoff Disease MeSH
Tay-Sachs Disease MeSH
DeCS ID: 19087
Unique ID: D001619
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/02
Revision Date: 2007/07/09
beta-N-Acetylhexosaminidases - Preferred
Concept UI M0002423
Scope note A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
Preferred term beta-N-Acetylhexosaminidases
Entry term(s) N Acetyl beta D hexosaminidase
N-Acetyl-beta-D-hexosaminidase
beta Hexosaminidase
beta N Acetyl D hexosaminidase
beta N Acetyl hexosaminidase
beta N Acetylhexosaminidase
beta N Acetylhexosaminidases
beta-Hexosaminidase
beta-N-Acetyl-D-hexosaminidase
beta-N-Acetyl-hexosaminidase
beta-N-Acetylhexosaminidase



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