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Descriptor English: Myosin-Light-Chain Kinase
Descriptor Spanish: Quinasa de Cadena Ligera de Miosina
Descriptor cinasa de cadena ligera de miosina
Entry term(s) miosina cinasa
miosina quinasa
Scope note: Enzima que fosforila las cadenas ligeras de la miosina en presencia de ATP formándose fosfato de miosina de cadenas ligeras y ADP, requiriendo calcio y calmodulina. La cadena ligera de 20kD es fosforilada más rápidamente que cualquier otro aceptor, pero pueden actuar como aceptores las cadenas ligeras de otras miosinas y la propia miosina. La enzima desempeña un papel central en la regulación de la contracción de la musculatura lisa.
Descriptor Portuguese: Quinase de Cadeia Leve de Miosina
Descriptor French: Myosin-Light-Chain Kinase
Entry term(s): Kinase, Myosin
Kinase, Myosin-Light-Chain
LCK, Myosin
Myosin Kinase
Myosin LCK
Myosin Light Chain Kinase
Myosin Regulatory Light Chain Kinase
Myosin Regulatory Light-Chain Kinase
Tree number(s): D08.811.913.696.620.682.700.125.500
D12.776.476.563.125.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009219
Scope note: An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.18
CAS Type 1 Name: ATP:myosin-light-chain O-phosphotransferase
Previous Indexing: Phosphotransferases, ATP (1966-1972)
Protein Kinases (1973-1986)
Public MeSH Note: 87
History Note: 87
Entry Version: MLCK
DeCS ID: 19253
Unique ID: D009219
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/16
Revision Date: 2015/11/24
Myosin-Light-Chain Kinase - Preferred
Concept UI M0014367
Scope note An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.
Preferred term Myosin-Light-Chain Kinase
Entry term(s) Kinase, Myosin
Kinase, Myosin-Light-Chain
LCK, Myosin
Myosin Kinase
Myosin LCK
Myosin Light Chain Kinase
Myosin Regulatory Light Chain Kinase
Myosin Regulatory Light-Chain Kinase



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