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Descriptor English: Colforsin
Descriptor Spanish: Colforsina
Descriptor Portuguese: Colforsina
Descriptor French: Colforsine
Entry term(s): Coleonol
Forskolin
N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl Ester HCl
NKH 477
NKH-477
NKH477
Tree number(s): D02.455.849.291.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005576
Scope note: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Adjuvants, Immunologic
Bronchodilator Agents
Cardiotonic Agents
Vasodilator Agents
Registry Number: 1F7A44V6OU
CAS Type 1 Name: 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-
Previous Indexing: Diterpenes (1974-1985)
Terpenes (1966-1973)
Public MeSH Note: 2014; see FORSKOLIN 1986-2013
History Note: 2014(1986)
DeCS ID: 19578
Unique ID: D005576
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1985/03/08
Revision Date: 2015/06/17
Colforsin - Preferred
Concept UI M0358301
Scope note Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Preferred term Colforsin
Entry term(s) Coleonol
Forskolin
N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl Ester HCl
NKH 477 - Narrower
Concept UI M0202704
Preferred term NKH 477
Entry term(s) NKH-477
NKH477



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