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Descriptor English: Ryanodine
Descriptor Spanish: Rianodina
Descriptor rianodina
Scope note: Metil-pirrol carboxilato de RYANIA que desestructura el CANAL DE LIBERACIÓN DE CALCIO DEL RECEPTOR DE RYANODINA para modificar la liberación de CALCIO del RETÍCULO SARCOPLÁSMICO que da lugar a alteración de la CONTRACCIÓN MUSCULAR. Se empleó previamente de modo experimental junto con TAPSIGARGINA y otros inhibidores de la recaptación de la ATPASA DEL CALCIO en el RETÍCULO SARCOPLÁSMICO.
Descriptor Portuguese: Rianodina
Descriptor French: Ryanodine
Tree number(s): D02.455.849.291.686
D03.132.740
D03.383.129.578.805
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D012433
Scope note: A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Registry Number: 15662-33-6
CAS Type 1 Name: Ryanodol, 3-(1H-pyrrole-2-carboxylate)
Previous Indexing: Alkaloids (1970-1974)
Public MeSH Note: 91; was see under ALKALOIDS 1975-90
History Note: 91(75); was see under ALKALOIDS 1975-90
DeCS ID: 12805
Unique ID: D012433
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/05/31
Ryanodine - Preferred
Concept UI M0019318
Scope note A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.
Preferred term Ryanodine



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