DeCS

Descriptor English:

Immunoglobulins

Descriptor Spanish:

Inmunoglobulinas

spanish from Spain

Descriptor	inmunoglobulinas
Entry term(s)	inmunoglobulina
Scope note:	Proteínas de múltiples subunidades que funcionan en la INMUNIDAD. Son producidas por los LINFOCITOS B a partir de los GENES DE LAS INMUNOGLOBULINAS. Están compuestos de dos cadenas pesadas y (CADENAS PESADAS DE LAS INMUNOGLOBULINAS) y de dos cadenas ligeras (CADENAS LIGERAS DE LAS INMUNOGLOBULINAS) con cadenas polipeptídicas secundarias adicionales dependiendo de sus isoformas. La variedad de isoformas incluye formas monoméricas o poliméricas y formas transmembranarias (RECEPTORES DE ANTÍGENOS DE LAS CÉLULAS B) o formas segregadas (ANTICUERPOS). Se dividen por la secuencia de aminoácidos de las cadenas pesadas en cinco clases (INMUNOGLOBULINA A, INMUNOGLOBULINA D, INMUNOGLOBULINA E, INMUNOGLOBULINA G, INMUNOGLOBULINA M) y varias subclases.

Descriptor Portuguese:

Imunoglobulinas

Descriptor French:

Immunoglobulines

Entry term(s):

Globulin, Immune
Globulins, Immune
Immune Globulin
Immune Globulins
Immunoglobulin

Tree number(s):

D12.776.124.486.485
D12.776.124.790.651
D12.776.377.715.548

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D007136

Scope note:

Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.

Annotation:

general: prefer specifics; /admin: consider also IMMUNOGLOBULINS, INTRAVENOUS; /defic permitted but consider also IMMUNOLOGIC DEFICIENCY SYNDROMES ; /ther use: consider also IMMUNOGLOBULIN THERAPY see IMMUNIZATION, PASSIVE; allotypes = IMMUNOGLOBULIN ALLOTYPES or specifics

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Concept UI	M0011122
Scope note	Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Preferred term	Immunoglobulins
Entry term(s)	Globulin, Immune Globulins, Immune Immune Globulin Immune Globulins Immunoglobulin

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