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Descriptor English: Immunoglobulins
Descriptor Spanish: Inmunoglobulinas
Descriptor Portuguese: Imunoglobulinas
Descriptor French: Immunoglobulines
Entry term(s): Globulins, Immune
Immune Globulins
Immunoglobulin
Tree number(s): D12.776.124.486.485
D12.776.124.790.651
D12.776.377.715.548
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007136
Scope note: Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Annotation: general: prefer specifics; /admin: consider also IMMUNOGLOBULINS, INTRAVENOUS; /defic permitted but consider also IMMUNOLOGIC DEFICIENCY SYNDROMES ; /ther use: consider also IMMUNOGLOBULIN THERAPY see IMMUNIZATION, PASSIVE; allotypes = IMMUNOGLOBULIN ALLOTYPES or specifics
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Gamma Globulins (1966-1969)
Public MeSH Note: 72; IMMUNE SERUM GLOBULIN was heading 1965; GLOBULINS, IMMUNE & IMMUNE GLOBULINS were see IMMUNOGLOBULINS, INTRAVENOUS 1992-93
Online Note: use IMMUNOGLOBULINS, INTRAVENOUS to search GLOBULINS, IMMUNE& IMMUNE GLOBULINS 1992-93
History Note: 72(70); IMMUNE SERUM GLOBULIN was heading 1965; GLOBULINS, IMMUNE & IMMUNE GLOBULINS were see IMMUNOGLOBULINS, INTRAVENOUS 1992-93
Related: Immunity MeSH
Paraproteinemias MeSH
DeCS ID: 22210
Unique ID: D007136
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1972/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/09
Immunoglobulins - Preferred
Concept UI M0011122
Scope note Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Preferred term Immunoglobulins
Entry term(s) Globulins, Immune
Immune Globulins
Immunoglobulin



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