| Descriptor English: | Immunoglobulin Variable Region | ||||||
| Descriptor Spanish: |
Región Variable de Inmunoglobulina
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| Descriptor Portuguese: | Região Variável de Imunoglobulina | ||||||
| Descriptor French: | Région variable d'immunoglobuline | ||||||
| Entry term(s): |
Antibody Fragment, Fv Antibody Fragments, Fv Fragment, Fv Fragment, Fv Antibody Fragment, Immunoglobulin Fv Fragments, Fv Fragments, Fv Antibody Fragments, Immunoglobulin Fv Framework Region, Ig Framework Region, Immunoglobulin Framework Regions, Ig Framework Regions, Immunoglobulin Fv Antibody Fragment Fv Antibody Fragments Fv Fragment Fv Fragment, Immunoglobulin Fv Fragments Fv Fragments, Immunoglobulin Ig Framework Region Ig Framework Regions Ig Variable Region Ig Variable Regions Immunoglobulin Framework Region Immunoglobulin Framework Regions Immunoglobulin Fv Fragment Immunoglobulin Fv Fragments Immunoglobulin V Immunoglobulin Variable Regions Regions, Immunoglobulin Variable Variable Region, Ig Variable Region, Immunoglobulin Variable Regions, Ig Variable Regions, Immunoglobulin |
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| Tree number(s): |
D12.644.541.500.650.500 D12.776.124.486.485.680.650.500 D12.776.124.486.485.797 D12.776.124.790.651.680.650.500 D12.776.124.790.651.797 D12.776.377.715.548.680.650.500 D12.776.377.715.548.797 G02.111.570.060.425 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D007135 | ||||||
| Scope note: | That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification DE drug effects EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PO poisoning RE radiation effects TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Immunologic Factors |
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| Previous Indexing: |
Antigenic Determinants (1972-1976) Binding Sites, Antibody (1973-1976) Immunoglobulin Fragments (1973-1976) Immunoglobulins, Fab (1973-1976) |
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| Public MeSH Note: | 84; was see under BINDING SITES, ANTIBODY 1977-83 |
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| History Note: | 84(77); was see under BINDING SITES, ANTIBODY 1977-83 |
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| Related: |
Binding Sites, Antibody
MeSH Immunoglobulin Domains MeSH | ||||||
| DeCS ID: | 22209 | ||||||
| Unique ID: | D007135 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1984/01/01 | ||||||
| Date of Entry: | 1976/04/16 | ||||||
| Revision Date: | 2015/11/20 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
PHENOMENA AND PROCESSES
Chemical Phenomena [G02]Chemical Phenomena
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Immunoglobulin Variable Region
- Preferred
Immunoglobulin Fv Fragments
- Related but not broader or narrower
Framework Region, Immunoglobulin
- Narrower
| Concept UI |
M0011118 |
| Scope note | That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions. |
| Preferred term | Immunoglobulin Variable Region |
| Entry term(s) |
Ig Variable Region Ig Variable Regions Immunoglobulin V Immunoglobulin Variable Regions Regions, Immunoglobulin Variable Variable Region, Ig Variable Region, Immunoglobulin Variable Regions, Ig Variable Regions, Immunoglobulin |
| Concept UI |
M0560635 |
| Scope note | The paired immunoglobulin fragments composed of the variable domains of the heavy and light chains. |
| Preferred term | Immunoglobulin Fv Fragments |
| Entry term(s) |
Antibody Fragment, Fv Antibody Fragments, Fv Fragment, Fv Fragment, Fv Antibody Fragment, Immunoglobulin Fv Fragments, Fv Fragments, Fv Antibody Fragments, Immunoglobulin Fv Fv Antibody Fragment Fv Antibody Fragments Fv Fragment Fv Fragment, Immunoglobulin Fv Fragments Fv Fragments, Immunoglobulin Immunoglobulin Fv Fragment |
| Concept UI |
M0011116 |
| Preferred term | Framework Region, Immunoglobulin |
| Entry term(s) |
Framework Region, Ig Framework Regions, Ig Framework Regions, Immunoglobulin Ig Framework Region Ig Framework Regions Immunoglobulin Framework Region Immunoglobulin Framework Regions |
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