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Descriptor English: Insulin-Like Growth Factor I
Descriptor Spanish: Factor I del Crecimiento Similar a la Insulina
Descriptor factor I de crecimiento insulinoide
Entry term(s) IGF-I
somatomedina C
Scope note: Péptido básico bien caracterizado. Se cree que es segregado por el hígado y que circula en la sangre. Tiene actividades de regulación del crecimiento, similares a la insulina y mitogénica. Este factor de crecimiento tiene una dependencia fundamental, pero no absoluta, de la HORMONA DEL CRECIMIENTO. Se cree que es principalmente activo en adultos, a diferencia del FACTOR II DE CRECIMIENTO INSULINOIDE, que es un factor fundamental del crecimiento fetal.
Descriptor Portuguese: Fator de Crescimento Insulin-Like I
Descriptor French: Facteur de croissance IGF-I
Entry term(s): IGF-1
IGF-I
IGF-I-SmC
Insulin Like Growth Factor I
Insulin Like Somatomedin Peptide I
Insulin-Like Somatomedin Peptide I
Somatomedin C
Tree number(s): D12.776.124.862.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007334
Scope note: A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 67763-96-6
CAS Type 1 Name: Insulin-like growth factor I
Previous Indexing: Growth Substances (1966-1985)
Insulin (1966-1985)
Peptides (1966-1985)
Somatomedins (1973-1985)
Sulfation Factor (1971-1972)
Public MeSH Note: 91; was see under SOMATOMEDINS 1986-90
History Note: 91(86); was see under SOMATOMEDINS 1986-90
Related: Receptor, IGF Type 1 MeSH
DeCS ID: 22312
Unique ID: D007334
NLM Classification: QU 107
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1985/04/25
Revision Date: 2006/07/05
Insulin-Like Growth Factor I - Preferred
Concept UI M0011434
Scope note A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.
Preferred term Insulin-Like Growth Factor I
Entry term(s) IGF-1
IGF-I
IGF-I-SmC
Insulin Like Growth Factor I
Insulin Like Somatomedin Peptide I
Insulin-Like Somatomedin Peptide I
Somatomedin C



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