| Descriptor English: | Receptor, IGF Type 1 | ||||||
| Descriptor Spanish: |
Receptor IGF Tipo 1
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| Descriptor Portuguese: | Receptor IGF Tipo 1 | ||||||
| Descriptor French: | Récepteur IGF de type 1 | ||||||
| Entry term(s): |
IGF 1 Receptor IGF I Receptor IGF Type 1 Receptor IGF-1 Receptor IGF-1 Receptors IGF-I Receptor Insulin Like Growth Factor I Receptor Insulin-Like-Growth Factor I Receptor Receptor, IGF I Receptor, IGF Type 1 alpha Subunit Receptor, IGF Type 1 beta Subunit Receptor, IGF-1 Receptor, IGF-I Receptor, Insulin-Like Growth Factor I Receptor, Insulin-Like Growth Factor Type 1 Receptors, IGF 1 Receptors, IGF-1 Receptors, Insulin-Like-Growth Factor I |
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| Tree number(s): |
D08.811.913.696.620.682.725.400.185 D12.776.476.568.400.185 D12.776.543.750.630.468 D12.776.543.750.750.400.780.400 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D017526 | ||||||
| Scope note: | A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.10.1 | ||||||
| Previous Indexing: |
Receptors, Endogenous Substances (1986-1992) |
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| Public MeSH Note: | 2000; see RECEPTOR, INSULIN-LIKE-GROWTH FACTOR I 1993-1999 |
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| History Note: | 2000(1993); |
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| Entry Version: | RECEPT IGF TYPE 1 |
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| Related: |
Insulin-Like Growth Factor I
MeSH Insulin-Like Growth Factor II MeSH | ||||||
| DeCS ID: | 30558 | ||||||
| Unique ID: | D017526 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1993/01/01 | ||||||
| Date of Entry: | 1992/05/29 | ||||||
| Revision Date: | 2016/05/31 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Receptor, IGF Type 1
- Preferred
Receptor, IGF Type 1 beta Subunit
- Narrower
Receptor, IGF Type 1 alpha Subunit
- Narrower
| Concept UI |
M0026587 |
| Scope note | A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain. |
| Preferred term | Receptor, IGF Type 1 |
| Entry term(s) |
IGF 1 Receptor IGF I Receptor IGF Type 1 Receptor IGF-1 Receptor IGF-1 Receptors IGF-I Receptor Insulin Like Growth Factor I Receptor Insulin-Like-Growth Factor I Receptor Receptor, IGF I Receptor, IGF-1 Receptor, IGF-I Receptor, Insulin-Like Growth Factor I Receptor, Insulin-Like Growth Factor Type 1 Receptors, IGF 1 Receptors, IGF-1 Receptors, Insulin-Like-Growth Factor I |
| Concept UI |
M0332241 |
| Preferred term | Receptor, IGF Type 1 beta Subunit |
| Concept UI |
M0332233 |
| Preferred term | Receptor, IGF Type 1 alpha Subunit |
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