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Descriptor English: Cortisone
Descriptor Spanish: Cortisona
Descriptor Portuguese: Cortisona
Descriptor French: Cortisone
Entry term(s): 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate
Adreson
Cortisone Acetate
Cortone Acetate
Tree number(s): D04.210.500.745.745.183
D06.472.040.585.478.195
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003348
Scope note: A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
Annotation:
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Inflammatory Agents
Registry Number: V27W9254FZ
CAS Type 1 Name: Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-
Public MeSH Note: /adverse effects /poisoning /toxicity were CORTISONE TOXICOLOGY 1963-65; /therapeutic use was CORTISONE, THERAPEUTIC 1965
History Note: /adv eff-pois-tox was CORTISONE TOXICOLOGY 1963-65; /ther use was CORTISONE, THERAPEUTIC 1965
DeCS ID: 22406
Unique ID: D003348
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1960/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/04/09
Cortisone - Preferred
Concept UI M0005219
Scope note A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
Preferred term Cortisone
Cortisone Acetate - Narrower
Concept UI M0064106
Scope note The acetate ester of cortisone that is used mainly for replacement therapy in adrenocortical insufficiency and in the treatment of many allergic and inflammatory disorders.
Preferred term Cortisone Acetate
Entry term(s) 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate
Cortone Acetate - Narrower
Concept UI M0433949
Preferred term Cortone Acetate
Adreson - Narrower
Concept UI M0351521
Preferred term Adreson



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