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Descriptor English: Eplerenone
Descriptor Spanish: Eplerenona
Descriptor Portuguese: Eplerenona
Descriptor French: Éplérénone
Entry term(s): 9,11-Epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone
Eplerenon
Inspra
Tree number(s): D02.540.383
D04.210.500.745.745.329
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077545
Scope note: A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Mineralocorticoid Receptor Antagonists
Antihypertensive Agents
Registry Number: 6995V82D0B
CAS Type 1 Name: Spiro(cyclopenta(7,8)phenanthro(4b,5-b)oxirene-7(3H),2'(3'H)-furan)-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7 R,9aS,9bR,10R)-
Public MeSH Note: 2019; EPLERENONE was indexed under SPIRONOLACTONE/analogs&derivatives 2000-2018
History Note: 2019 (2000)
DeCS ID: 57670
Unique ID: D000077545
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/09
Eplerenone - Preferred
Concept UI M0371594
Scope note A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.
Preferred term Eplerenone
Entry term(s) Eplerenon
Inspra - Narrower
Concept UI M0439953
Preferred term Inspra
9,11-Epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone - Related but not broader or narrower
Concept UI M000640866
Preferred term 9,11-Epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone



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