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Descriptor English: DNA Restriction-Modification Enzymes
Descriptor Spanish: Enzimas de Restricción-Modificación del ADN
Descriptor enzimas de restricción-modificación del ADN
Entry term(s) enzima de restricción y modificación del ADN
enzima de restricción-modificación del ADN
sistema de restricción y modificación
sistema de restricción-modificación
sistemas de restricción-modificación
Scope note: Sistemas constituidos por dos enzimas, una metilasa de modificación y una endonucleasa de restricción. Están íntimamente relacionados en su especificidad y protegen el ADN de una determinada especie bacteriana. La metilasa añade grupos metilo a los residuos de adenina o citosina en la misma secuencia que constituye el sitio de unión de la enzima de restricción. La metilación hace que el sitio diana se vuelva resistente a la restricción, protegiendo así al ADN de la segmentación.
Descriptor Portuguese: Enzimas de Restrição-Modificação do DNA
Descriptor French: Enzymes de restriction-modification de l'ADN
Entry term(s): DNA Restriction Modification Enzyme
DNA Restriction Modification Enzymes
DNA Restriction-Modification Enzyme
Enzyme, DNA Restriction-Modification
Enzymes, DNA Restriction-Modification
Modification System, Restriction
Modification Systems, Restriction
Restriction Modification System
Restriction Modification Systems
Restriction-Modification Enzyme, DNA
Restriction-Modification Enzymes, DNA
Restriction-Modification System
Restriction-Modification Systems
System, Restriction Modification
System, Restriction-Modification
Systems, Restriction Modification
Systems, Restriction-Modification
Tree number(s): D08.811.150
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015280
Scope note: Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: DNA Restriction Enzymes (1975-1988)
Methyltransferases (1971-1988)
Public MeSH Note: 89
History Note: 89
Entry Version: RESTRICT MOD ENZYMES
DeCS ID: 23619
Unique ID: D015280
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/23
Revision Date: 2020/05/27
DNA Restriction-Modification Enzymes - Preferred
Concept UI M0023522
Scope note Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.
Preferred term DNA Restriction-Modification Enzymes
Entry term(s) DNA Restriction Modification Enzyme
DNA Restriction Modification Enzymes
DNA Restriction-Modification Enzyme
Enzyme, DNA Restriction-Modification
Enzymes, DNA Restriction-Modification
Modification System, Restriction
Modification Systems, Restriction
Restriction Modification System
Restriction Modification Systems
Restriction-Modification Enzyme, DNA
Restriction-Modification Enzymes, DNA
Restriction-Modification System
Restriction-Modification Systems
System, Restriction Modification
System, Restriction-Modification
Systems, Restriction Modification
Systems, Restriction-Modification



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