| Descriptor English: | DNA Modification Methylases | ||||||
| Descriptor Spanish: |
Metilasas de Modificación del ADN
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| Descriptor Portuguese: | Metilases de Modificação do DNA | ||||||
| Descriptor French: | DNA modification methylases | ||||||
| Entry term(s): |
DNA Modification Methyltransferases Methylases, DNA Modification Methylases, Modification Methyltransferases, DNA Modification Modification Methylases Modification Methylases, DNA Modification Methyltransferases, DNA |
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| Tree number(s): |
D08.811.150.240 D08.811.913.555.500.350 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D015254 | ||||||
| Scope note: | Enzymes that are part of the restriction-modification systems. They are responsible for producing a species-characteristic methylation pattern, on either adenine or cytosine residues, in a specific short base sequence in the host cell's own DNA. This methylated sequence will occur many times in the host-cell DNA and remain intact for the lifetime of the cell. Any DNA from another species which gains entry into a living cell and lacks the characteristic methylation pattern will be recognized by the restriction endonucleases of similar specificity and destroyed by cleavage. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.1.1.- | ||||||
| Previous Indexing: |
DNA (Cytosine-5-)-Methyltransferase (1975-1988) Methyltransferases (1971-1988) |
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| Public MeSH Note: | 1989 |
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| History Note: | 1989 |
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| DeCS ID: | 23613 | ||||||
| Unique ID: | D015254 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1989/01/01 | ||||||
| Date of Entry: | 1988/05/17 | ||||||
| Revision Date: | 2003/07/09 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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DNA Modification Methylases
- Preferred
| Concept UI |
M0023492 |
| Scope note | Enzymes that are part of the restriction-modification systems. They are responsible for producing a species-characteristic methylation pattern, on either adenine or cytosine residues, in a specific short base sequence in the host cell's own DNA. This methylated sequence will occur many times in the host-cell DNA and remain intact for the lifetime of the cell. Any DNA from another species which gains entry into a living cell and lacks the characteristic methylation pattern will be recognized by the restriction endonucleases of similar specificity and destroyed by cleavage. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. |
| Preferred term | DNA Modification Methylases |
| Entry term(s) |
DNA Modification Methyltransferases Methylases, DNA Modification Methylases, Modification Methyltransferases, DNA Modification Modification Methylases Modification Methylases, DNA Modification Methyltransferases, DNA |
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