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Descriptor English: Fibrinogens, Abnormal
Descriptor Spanish: Fibrinógenos Anormales
Descriptor fibrinógenos anormales
Scope note: Fibrinógenos que tienen un defecto funcional como consecuencia de una o más sustituciones de aminoácidos en la secuencia de aminoácidos del fibrinógeno normal. Las anomalías de la molécula de fibrinógeno pueden alterar cualquiera de las principales etapas implicadas en la conversión del fibrinógeno a fibrina estabilizada. como el desdoblamiento de fibrinopéptidos por la trombina, polimerización y entrecruzamiento de fibrina. Las disfibrinogenemias resultantes pueden ser clínicamente silentes o pueden asociarse con hemorragia, trombosis o defectos en la cicatrización de heridas.
Descriptor Portuguese: Fibrinogênios Anormais
Descriptor French: Fibrinogènes anormaux
Entry term(s): Abnormal Fibrinogens
Tree number(s): D12.776.124.050.250.265
D12.776.124.125.500.265
D23.119.490.265
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015241
Scope note: Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Fibrinogen (1966-1988)
Public MeSH Note: 89
History Note: 89
Entry Version: FIBRINOGENS ABNORM
DeCS ID: 23634
Unique ID: D015241
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/16
Revision Date: 2018/06/30
Fibrinogens, Abnormal - Preferred
Concept UI M0023429
Scope note Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.
Preferred term Fibrinogens, Abnormal
Entry term(s) Abnormal Fibrinogens



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