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Descriptor English: Fibrinogen
Descriptor Spanish: Fibrinógeno
Descriptor fibrinógeno
Entry term(s) factor I
factor I de la coagulación
Scope note: Glicoproteína plasmática coagulada por la trombina, compuesta de un dímero de tres pares no idénticos de cadenas polipeptídicas (alfa, beta, gamma) unidas por puentes disulfuro. La coagulación del fibrinógeno es un cambio sol-gel que implica complejas disposiciones moleculares: mientras que el fibrinógeno es desdoblado por la trombina para formar los polipéptidos A y B, la acción proteolítica de otras enzimas da lugar a diferentes productos de degradación del fibrinógeno.
Descriptor Portuguese: Fibrinogênio
Descriptor French: Fibrinogène
Entry term(s): Blood Coagulation Factor I
Coagulation Factor I
Factor I
Factor I, Coagulation
gamma Fibrinogen
gamma-Fibrinogen
Tree number(s): D12.776.124.050.250
D12.776.124.125.500
D12.776.811.300
D23.119.490
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005340
Scope note: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Annotation: a blood coag factor: do not confuse entry term FACTOR I with COMPLEMENT FACTOR I
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Afibrinogenemia
Registry Number: 9001-32-5
CAS Type 1 Name: Fibrinogens
Related: Coagulants MeSH
Hemostatics MeSH
DeCS ID: 22179
Unique ID: D005340
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/28
Fibrinogen - Preferred
Concept UI M0008430
Scope note Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Preferred term Fibrinogen
Entry term(s) Blood Coagulation Factor I
Coagulation Factor I
Factor I
Factor I, Coagulation
gamma-Fibrinogen - Narrower
Concept UI M0008431
Preferred term gamma-Fibrinogen
Entry term(s) gamma Fibrinogen



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