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Descriptor English:

Ofloxacin

Descriptor Spanish:

Ofloxacino

Spanish from Spain

Descriptor	ofloxacin
Scope note:	Fluoroquinolona sintética, un agente antibacteriano que inhibe la actividad de superenrollamiento de la ADN GIRASA bacteriana, impidiendo la REPLICACIÓN DEL ADN.

Descriptor Portuguese:

Ofloxacino

Descriptor French:

Ofloxacine

Tree number(s):

D03.633.100.810.835.830.250.500

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D015242

Scope note:

A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Anti-Infective Agents, Urinary
Anti-Bacterial Agents
Topoisomerase II Inhibitors
Cytochrome P-450 CYP1A2 Inhibitors

Registry Number:

A4P49JAZ9H

CAS Type 1 Name:

(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid

DeCS ID:

23786

Unique ID:

D015242

NLM Classification:

QV 250