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Descriptor English: Transducin
Descriptor Spanish: Transducina
Descriptor transducina
Entry term(s) proteína G inhibidora Gt
proteína G transducina Gt
transducina alfa
transducina beta
transducina gamma
Scope note: Proteína heterotrimérica de unión a GTP, mediadora de la señal de activación por la luz de la rodopsina fotolizada a la fosfodiesterasa de GMP cíclico y fundamental en el proceso de excitación visual. La activación de la rodopsina en la membrana externa de los bastones y de los conos provoca que el GTP se una a la transducina, con la subsiguiente disociación del complejo subunidad alfa-GTP de las subunidades beta-gamma de la transducina. El complejo subunidad alfa-GTP activa la fosfodiesterasa de GMP cíclico que cataliza la hidrólisis de GMP cíclico a 5'-GMP. Esto conduce al cierre de los canales de sodio y calcio y en consecuencia a la hiperpolarización de los bastones.
Descriptor Portuguese: Transducina
Descriptor French: Transducine
Entry term(s): G Protein, Inhibitory Gt
G-Protein Gt, Transducin
G-Protein, Inhibitory Gt
Gt G-Protein, Inhibitory
Gt, Transducin G Protein
Gt, Transducin G-Protein
Inhibitory Gt G-Protein
Transducin G-Protein (Gt)
Transducin G-Protein Gt
Transducin, alpha Subunit
Transducin, beta Subunit
Transducin, gamma Subunit
alpha Subunit Transducin
alpha Transducin
alpha-Transducin
beta Subunit Transducin
beta Transducin
beta-Transducin
gamma Subunit Transducin
gamma Transducin
gamma-Transducin
Tree number(s): D08.811.277.040.330.300.200.800
D12.776.157.325.332.940
D12.776.476.338.200.800
D12.776.543.325.800
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015293
Scope note: A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.
Annotation: alpha, beta and gamma transducins refer to its subunits
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.6.5.1
Previous Indexing: Guanine Nucleotide Regulatory Protein (1985-1988)
Membrane Proteins (1980-1988)
Public MeSH Note: 89
History Note: 89
DeCS ID: 23850
Unique ID: D015293
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/24
Revision Date: 2017/06/30
Transducin - Preferred
Concept UI M0023545
Scope note A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.
Preferred term Transducin
Entry term(s) G Protein, Inhibitory Gt
G-Protein Gt, Transducin
G-Protein, Inhibitory Gt
Gt G-Protein, Inhibitory
Gt, Transducin G Protein
Gt, Transducin G-Protein
Inhibitory Gt G-Protein
Transducin G-Protein (Gt)
Transducin G-Protein Gt
gamma-Transducin - Narrower
Concept UI M0023548
Preferred term gamma-Transducin
Entry term(s) Transducin, gamma Subunit
gamma Subunit Transducin
gamma Transducin
beta-Transducin - Narrower
Concept UI M0023547
Preferred term beta-Transducin
Entry term(s) Transducin, beta Subunit
beta Subunit Transducin
beta Transducin
alpha-Transducin - Narrower
Concept UI M0023546
Preferred term alpha-Transducin
Entry term(s) Transducin, alpha Subunit
alpha Subunit Transducin
alpha Transducin



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