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Descriptor English: Sulbactam
Descriptor Spanish: Sulbactam
Descriptor Portuguese: Sulbactam
Descriptor French: Sulbactam
Entry term(s): Bétamaze
CP 45899
CP-45899
CP45899
Combactam
Penicillanic Acid Sulfone
Sodium, Sulbactam
Sulbactam Sodium
Sulfone, Penicillanic Acid
Tree number(s): D02.065.589.099.750.812
D02.886.108.750.812
D03.633.100.300.750.812
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013407
Scope note: A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
beta-Lactamase Inhibitors
Registry Number: S4TF6I2330
CAS Type 1 Name: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, (2S-cis)-
Previous Indexing: Beta Lactamases/antagonists & inhibitors (1979-1987)
Enzyme Inhibitors (1975-1987)
Enzymes/antagonists & inhibitors (1966-1974)
Penicillanic Acids (1971-1987)
Public MeSH Note: 88
History Note: 88
DeCS ID: 24415
Unique ID: D013407
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1988/01/01
Date of Entry: 1987/04/09
Revision Date: 2017/05/24
Sulbactam - Preferred
Concept UI M0020733
Scope note A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
Preferred term Sulbactam
Entry term(s) Penicillanic Acid Sulfone
Sulfone, Penicillanic Acid
CP-45899 - Narrower
Concept UI M0351143
Preferred term CP-45899
Entry term(s) CP 45899
CP45899
Sulbactam Sodium - Narrower
Concept UI M0020734
Preferred term Sulbactam Sodium
Entry term(s) Sodium, Sulbactam
Combactam - Narrower
Concept UI M0475792
Preferred term Combactam
Entry term(s) Bétamaze



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