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Descriptor English: 2-Amino-5-phosphonovalerate
Descriptor Spanish: 2-Amino-5-fosfonovalerato
Descriptor 2-amino-5-fosfonovalerato
Entry term(s) ácido 2-amino-5-fosfonopentanoico
ácido 2-amino-5-fosfonovalérico
Scope note: El D-enantiómero es un antagonista potente y específico de los receptores NMDA glutamato (FRECEPTORES, N-METIL-D-ASPARTATO). La forma L es inactiva en los receptores de NMDA pero puede afectar a los receptores de aminoácidos excitatorios (2-amino-4-fosfonobutirato;APB).
Descriptor Portuguese: 2-Amino-5-fosfonovalerato
Descriptor French: Amino-2 phosphono-5 valérate
Entry term(s): 2 Amino 5 phosphonopentanoate
2 Amino 5 phosphonopentanoic Acid
2 Amino 5 phosphonovalerate
2 Amino 5 phosphonovaleric Acid
2-APV
2-Amino-5-phosphonopentanoate
2-Amino-5-phosphonopentanoic Acid
2-Amino-5-phosphonovaleric Acid
5 Phosphononorvaline
5-Phosphononorvaline
d-APV
dl-APV
Tree number(s): D12.125.070.950.100
D12.125.740.025
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015763
Scope note: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Excitatory Amino Acid Antagonists
Registry Number: 76726-92-6
CAS Type 1 Name: Norvaline, 5-phosphono-
Previous Indexing: Anticonvulsants (1966-1989)
Valine (1966-1974)
Valine/analogs & derivatives (1975-1989)
Public MeSH Note: 90
History Note: 90
DeCS ID: 24515
Unique ID: D015763
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2007/07/09
2-Amino-5-phosphonovalerate - Preferred
Concept UI M0024150
Scope note The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Preferred term 2-Amino-5-phosphonovalerate
Entry term(s) 2 Amino 5 phosphonopentanoate
2 Amino 5 phosphonopentanoic Acid
2 Amino 5 phosphonovalerate
2 Amino 5 phosphonovaleric Acid
2-APV
2-Amino-5-phosphonopentanoate
2-Amino-5-phosphonopentanoic Acid
2-Amino-5-phosphonovaleric Acid
5 Phosphononorvaline
5-Phosphononorvaline
dl-APV - Related but not broader or narrower
Concept UI M0024152
Preferred term dl-APV
d-APV - Related but not broader or narrower
Concept UI M0024151
Preferred term d-APV



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