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Descriptor English: Complement C1q
Descriptor Spanish: Complemento C1q
Descriptor complemento C1q
Scope note: Subcomponente del complemento C1, compuesto de seis copias de tres cadenas polipeptídicas (A, B y C), cada una de ellas codificada por un gen distinto (C1QA, C1QB, C1QC). Este complejo se halla dispuesto en nueve subunidades (seis dímeros con puentes disulfuro de A y B, y tres homodímeros con puentes disulfuro de C). C1q tiene sitios de unión para anticuerpos (la cadena pesada de la INMUNOGLOBULINA G o INMUNOGLOBULINA M). La interacción de C1q y de la inmunoglobulina activa las dos proenzimas COMPLEMENTO C1R y COMPLEMENTO C1S, iniciando así la cascada de la ACTIVACIÓN DEL COMPLEMENTO por medio de la VÍA CLÁSICA DEL COMPLEMENTO.
Descriptor Portuguese: Complemento C1q
Descriptor French: Complément C1q
Entry term(s): C1q Complement
C1q, Complement
Complement 1q
Complement Component 1q
Complement, C1q
Component 1q, Complement
Tree number(s): D12.776.124.486.274.050.270
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015922
Scope note: A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Registry Number: 80295-33-6
CAS Type 1 Name: Complement C1q
Previous Indexing: Complement 1 (1980-1989)
Complement Activating Enzymes (1979-1989)
Public MeSH Note: 2006; see COMPLEMENT 1Q 1990-2005
History Note: 2006 (1990)
DeCS ID: 24573
Unique ID: D015922
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2005/06/30
Complement C1q - Preferred
Concept UI M0024366
Scope note A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
Preferred term Complement C1q
Entry term(s) C1q Complement
C1q, Complement
Complement 1q
Complement Component 1q
Complement, C1q
Component 1q, Complement



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