Search
Descriptor English: Complement C1s
Descriptor Spanish: Complemento C1s
Descriptor complemento C1s
Scope note: Subcomponente de 77 kDa del complemento C1, codificado por el gen C1S, que es una SERINA PROTEASA que existe como proenzima (homodímero) en el complejo del complemento C1 intacto. Tras la unión del COMPLEMENTO C1Q a los anticuerpos, el COMPLEMENTO C1R activado divide el C1s en dos cadenas -A (pesada) y B (ligera, la serina proteasa)- unidas por enlaces disulfuro que dan lugar al C1s activo. El C1s activado, a su vez, escinde el COMPLEMENTO C2 y el COMPLEMENTO C4 para formar C4b2a (CONVERTASA C3 DE LA VÍA CLÁSICA DEL COMPLEMENTO).
Descriptor Portuguese: Complemento C1s
Descriptor French: Complément C1s
Entry term(s): C 1 Esterase
C1 Esterase
C1s Complement
C1s, Complement
Complement 1 Esterase
Complement 1s
Complement Component 1s
Complement, C1s
Component 1s, Complement
Esterase, C 1
Esterase, C1
Esterase, Complement 1
Tree number(s): D08.811.277.300.290
D12.776.124.486.274.045.290
D12.776.124.486.274.050.290
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003173
Scope note: A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Registry Number: EC 3.4.21.42
Previous Indexing: Complement 1 (1975-1977)
Esterases (1966-1977)
Public MeSH Note: 2006; see COMPLEMENT 1S 1990-2005; for COMPLEMENT 1 ESTERASE see COMPLEMENT ACTIVATING ENZYMES 1978-1989
History Note: 2006 (1978)
DeCS ID: 28242
Unique ID: D003173
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1977/05/16
Revision Date: 2006/07/05
Complement C1s - Preferred
Concept UI M0004925
Scope note A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
Preferred term Complement C1s
Entry term(s) C 1 Esterase
C1 Esterase
C1s Complement
C1s, Complement
Complement 1 Esterase
Complement 1s
Complement Component 1s
Complement, C1s
Component 1s, Complement
Esterase, C 1
Esterase, C1
Esterase, Complement 1



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey