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Descriptor English: Complement C1
Descriptor Spanish: Complemento C1
Descriptor complemento C1
Entry term(s) C1 del complemento
complemento 1
componente 1 del complemento
Scope note: El primer componente del complemento que actúa en la activación de la VÍA CLÁSICA DEL COMPLEMENTO. Es un complejo trimolecular dependiente del calcio compuesto de tres subcomponentes: COMPLEMENTO C1Q, COMPLEMENTO C1R Y COMPLEMENTO C1S en proporciones de 1:2:2. Cuando el C1 intacto se une al menos a dos anticuerpos (que implican C1q), C1r y C1s son activados secuencialmente, lo que lleva a etapas posteriores en la cascada de la ACTIVACIÓN DEL COMPLEMENTO.
Descriptor Portuguese: Complemento C1
Descriptor French: Complément C1
Entry term(s): C1 Complement
C1, Complement
Complement 1
Complement Component 1
Complement, C1
Component 1, Complement
Tree number(s): D12.776.124.486.274.050
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003172
Scope note: The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
Annotation: /antag permitted but consider also COMPLEMENT C1 INACTIVATOR PROTEINS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Calcium (1966-1974)
Complement (1968-1974)
Public MeSH Note: 2006; see COMPLEMENT 1 1978-2005, see COMPLEMENT 1975-1977
History Note: 2006 (1975)
DeCS ID: 22133
Unique ID: D003172
NLM Classification: QW 680
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2013/07/09
Complement C1 - Preferred
Concept UI M0004924
Scope note The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
Preferred term Complement C1
Entry term(s) C1 Complement
C1, Complement
Complement 1
Complement Component 1
Complement, C1
Component 1, Complement



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