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Descriptor English: Cytochalasin D
Descriptor Spanish: Citocalasina D
Descriptor citocalasina D
Scope note: Metabolito fúngico que al bloquear la formación de estructuras microfilamentosas contráctiles impide la segmentación citoplasmática que da lugar a la formación de células multinucleadas, inhibe de forma reversible la motilidad celular y la indución de extrusión celular. Se ha informado de otros efectos tales como la inhibición de la polimerizacion de la actina, la síntesis de ADN, la motilidad espermática, el transporte de glucosa, la secreción tiroidea, y la liberación de hormona del crecimiento.
Descriptor Portuguese: Citocalasina D
Descriptor French: Cytochalasine D
Tree number(s): D03.633.100.473.231.450
D23.946.587.370.450
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015638
Scope note: A fungal metabolite that blocks cytoplasmic cleavage by blocking formation of contractile microfilament structures resulting in multinucleated cell formation, reversible inhibition of cell movement, and the induction of cellular extrusion. Additional reported effects include the inhibition of actin polymerization, DNA synthesis, sperm motility, glucose transport, thyroid secretion, and growth hormone release.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Nucleic Acid Synthesis Inhibitors
Registry Number: 22144-77-0
CAS Type 1 Name: (11)Cytochalasa-6(12),13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E,21R)-
Previous Indexing: Cytochalasins (1973-1989)
Public MeSH Note: 90
History Note: 90
DeCS ID: 24598
Unique ID: D015638
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/15
Revision Date: 2016/05/28
Cytochalasin D - Preferred
Concept UI M0023976
Scope note A fungal metabolite that blocks cytoplasmic cleavage by blocking formation of contractile microfilament structures resulting in multinucleated cell formation, reversible inhibition of cell movement, and the induction of cellular extrusion. Additional reported effects include the inhibition of actin polymerization, DNA synthesis, sperm motility, glucose transport, thyroid secretion, and growth hormone release.
Preferred term Cytochalasin D



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