DeCS

Descriptor English:

Erythromycin Ethylsuccinate

Descriptor Spanish:

Etilsuccinato de Eritromicina

Spanish from Spain

Descriptor	etilsuccinato de eritromicina
Entry term(s)	monomicina
Scope note:	Antibiótico macrólido producido por Streptpmyces erythreus. Este compuesto es un éster de la eritromicina base y ácido succínico. Actúa principalmente como agente bacteriostático. En los organismos sensibles inhibe la síntesis de proteínas al unirse a las subunidades ribosómicas 50S. Este proceso de unión inhibe la actividad peptidil transferasa e interfiere en la translocación de los aminoácidos durante la traducción y ensamblaje de las proteínas.

Descriptor Portuguese:

Etilsuccinato de Eritromicina

Descriptor French:

Éthylsuccinate d'érythromycine

Entry term(s):

Éthyl-succinate d'érythromycine

Tree number(s):

D02.540.576.500.992.260

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D015643

Scope note:

A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Anti-Bacterial Agents
Enzyme Inhibitors
Gastrointestinal Agents
Protein Synthesis Inhibitors

Registry Number:

1014KSJ86F

CAS Type 1 Name:

Erythromycin, 2'-(ethyl butanedioate)

DeCS ID:

24629

Unique ID:

D015643

Documents indexed in the Virtual Health Library (VHL):

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