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Descriptor English: Gene Products, pol
Descriptor Spanish: Productos del Gen pol
Descriptor productos del gen pol
Entry term(s) poliproteínas pol
proteína pol
Scope note: Proteínas retrovirales codificadas por el gen pol. Habitualmente se sintetizan como precursores proteínicos (POLIPROTEÍNAS) y posteriormente se escinden para constituir los productos finales, como la transcriptasa inversa, la endonucleasa-integrasa y la proteasa viral. En ocasiones, se sintetizan como PROTEÍNAS DE FUSIÓN GAG-POL. El término pol es una abreviatura de polimerasa, la clase de enzimas de la transcriptasa inversa.
Descriptor Portuguese: Produtos do Gene pol
Descriptor French: Produits du gène pol
Entry term(s): Gene Product, pol
Polyprotein, pol
Polyproteins, pol
Protein, pol
pol Gene Product
pol Gene Products
pol Polyprotein
pol Polyproteins
pol Protein
Tree number(s): D12.776.775.360
D12.776.964.775.375
D12.776.964.900.750.500
D12.776.964.970.600.850.375
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015684
Scope note: Retroviral proteins coded by the pol gene. They are usually synthesized as a protein precursor (POLYPROTEINS) and later cleaved into final products that include reverse transcriptase, endonuclease/integrase, and viral protease. Sometimes they are synthesized as a gag-pol fusion protein (FUSION PROTEINS, GAG-POL). Pol is short for polymerase, the enzyme class of reverse transcriptase.
Annotation: coord with specific virus (IM)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Retroviridae Proteins (1983-1989)
Reverse Transcriptase (1977-1989)
Viral Proteins (1977-1989)
Public MeSH Note: 90
History Note: 90
Related: Endonucleases MeSH
Peptide Hydrolases MeSH
RNA-Directed DNA Polymerase MeSH
DeCS ID: 24677
Unique ID: D015684
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/10/12
Revision Date: 2005/06/30
Gene Products, pol - Preferred
Concept UI M0024059
Scope note Retroviral proteins coded by the pol gene. They are usually synthesized as a protein precursor (POLYPROTEINS) and later cleaved into final products that include reverse transcriptase, endonuclease/integrase, and viral protease. Sometimes they are synthesized as a gag-pol fusion protein (FUSION PROTEINS, GAG-POL). Pol is short for polymerase, the enzyme class of reverse transcriptase.
Preferred term Gene Products, pol
Entry term(s) Gene Product, pol
Polyprotein, pol
Polyproteins, pol
Protein, pol
pol Gene Product
pol Gene Products
pol Polyprotein
pol Polyproteins
pol Protein



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